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Quinapril, marketed as Accupril, is associated with significant safety warnings and precautions. It is essential that both patients and healthcare providers are aware of these to ensure safe usage of the medication:

• Pregnancy Risks: Quinapril can cause severe and potentially fatal harm to an unborn child. It should not be used during pregnancy. If you are pregnant, planning to become pregnant, or think you might be pregnant, inform your doctor immediately. Discuss alternative treatments for managing blood pressure with your healthcare provider if pregnancy is a possibility.

• Angioedema (Swelling): There is a risk of developing angioedema, a serious condition causing swelling of the face, throat, and tongue, which can obstruct breathing. This risk is higher if you are Black, older, or female, and if you have a history of angioedema. Seek immediate medical assistance if you experience any unusual swelling, stomach pain, or difficulty breathing, and discontinue quinapril if this occurs.

• Low Blood Pressure: Quinapril may cause a significant drop in blood pressure, leading to dizziness, tiredness, or lightheadedness, especially when starting the medication or increasing the dose. Stay hydrated, rise slowly from sitting or lying positions, and consult a healthcare provider if these symptoms occur, particularly if they lead to a fall.

• Kidney Concerns: While often beneficial for kidney health, quinapril can exacerbate existing kidney issues, particularly in individuals with renal artery stenosis or heart failure. Regular kidney function tests are recommended during treatment. Notify your provider if you notice a decrease in urination frequency.

• High Potassium Levels: Quinapril can elevate potassium levels in the body, which might be hazardous. This is more likely if you have diabetes or kidney issues or are taking medications that increase potassium. Be vigilant for symptoms like nausea, muscle weakness, or irregular heartbeats, and inform your healthcare provider if they occur.

• Liver Problems: Rarely, quinapril use may lead to liver issues, including a blocked bile duct. Regular liver function tests may be necessary. Report any signs of liver problems, such as fatigue, abdominal pain, or jaundice, to your provider.

• Contraindications: Quinapril should not be taken if you have a history of angioedema. Avoid concurrent use with aliskiren in individuals with diabetes, and do not use within 36 hours of taking neprilysin inhibitors like Entresto.

This information is crucial for ensuring the safe and effective use of quinapril. Always consult your healthcare provider for guidance tailored to your specific health needs.

Common side effects:

• Dizziness
• Lightheadedness
• Tiredness
• Dry cough
• Nausea
• Vomiting
• Headache
• Low blood pressure

Serious side effects:

• High potassium levels (muscle weakness or irregular heartbeat)
• Fainting
• Kidney problems (changes in urine output)
• Liver problems (persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, dark urine)
• Severe allergic reaction (rash, severe dizziness, swelling of face, tongue, or throat, trouble breathing)

Quinapril, also known as Accupril, can interact with a variety of medications and supplements. It is crucial to inform your doctor and pharmacist about all the medications and supplements, whether prescribed, over-the-counter, vitamins, or herbal remedies, that you are currently using. Not all potential interactions are listed here.

1. Advised Against Use: Quinapril should not be used with Aliskiren and sacubitril. If you are on these medications, your doctor might consider alternative treatments.

2. Use with Caution: Some medications are generally not recommended for use with quinapril, but may be necessary in certain situations. In such cases, your doctor may adjust the dosage or frequency. These include Amiloride, Azathioprine, certain angiotensin receptor blockers (ARBs) like Losartan and Valsartan, Lithium, drugs that affect immune function like Everolimus and Sirolimus, and potassium supplements.

3. Potential for Increased Side Effects: Combining quinapril with certain drugs may raise the risk of side effects. However, this combination may be the most effective treatment plan for you. Examples include various pain relievers such as Ibuprofen and Naproxen, diuretics like Furosemide, and other medications like gold sodium thiomalate.

Additionally, quinapril contains Magnesium, which can interfere with the absorption of certain drugs if taken simultaneously. Such drugs include some antibiotics (like Ciprofloxacin and doxycycline), thyroid medications, and osteoporosis treatments. Consult your healthcare provider for guidance on timing your doses.

Lastly, inform your healthcare provider if you are undergoing allergy treatments for bee or wasp stings, as serious interactions can occur with quinapril. Always keep your doctors informed about all the medications you are using to ensure safe and effective treatment.