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Quinapril, marketed as Accupril, is associated with significant safety warnings and precautions. It is essential that both patients and healthcare providers are aware of these to ensure safe usage of the medication:

• Pregnancy Risks: Quinapril can cause severe and potentially fatal harm to an unborn child. It should not be used during pregnancy. If you are pregnant, planning to become pregnant, or think you might be pregnant, inform your doctor immediately. Discuss alternative treatments for managing blood pressure with your healthcare provider if pregnancy is a possibility.

• Angioedema (Swelling): There is a risk of developing angioedema, a serious condition causing swelling of the face, throat, and tongue, which can obstruct breathing. This risk is higher if you are Black, older, or female, and if you have a history of angioedema. Seek immediate medical assistance if you experience any unusual swelling, stomach pain, or difficulty breathing, and discontinue quinapril if this occurs.

• Low Blood Pressure: Quinapril may cause a significant drop in blood pressure, leading to dizziness, tiredness, or lightheadedness, especially when starting the medication or increasing the dose. Stay hydrated, rise slowly from sitting or lying positions, and consult a healthcare provider if these symptoms occur, particularly if they lead to a fall.

• Kidney Concerns: While often beneficial for kidney health, quinapril can exacerbate existing kidney issues, particularly in individuals with renal artery stenosis or heart failure. Regular kidney function tests are recommended during treatment. Notify your provider if you notice a decrease in urination frequency.

• High Potassium Levels: Quinapril can elevate potassium levels in the body, which might be hazardous. This is more likely if you have diabetes or kidney issues or are taking medications that increase potassium. Be vigilant for symptoms like nausea, muscle weakness, or irregular heartbeats, and inform your healthcare provider if they occur.

• Liver Problems: Rarely, quinapril use may lead to liver issues, including a blocked bile duct. Regular liver function tests may be necessary. Report any signs of liver problems, such as fatigue, abdominal pain, or jaundice, to your provider.

• Contraindications: Quinapril should not be taken if you have a history of angioedema. Avoid concurrent use with aliskiren in individuals with diabetes, and do not use within 36 hours of taking neprilysin inhibitors like Entresto.

This information is crucial for ensuring the safe and effective use of quinapril. Always consult your healthcare provider for guidance tailored to your specific health needs.

Common side effects:

• Dizziness
• Lightheadedness
• Tiredness
• Dry cough
• Nausea
• Vomiting
• Headache
• Low blood pressure

Serious side effects:

• High potassium levels (muscle weakness or irregular heartbeat)
• Fainting
• Kidney problems (changes in urine output)
• Liver problems (persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, dark urine)
• Severe allergic reaction (rash, severe dizziness, swelling of face, tongue, or throat, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Aliskiren
• Sacubitril
• Bee/wasp sting allergy desensitization injections

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiloride
• Azathioprine
• Losartan
• Valsartan
• Lithium
• Everolimus
• Sirolimus
• Potassium supplements

Interactions with low risk that usually do not require a change in therapy:

• Ibuprofen
• Naproxen
• Furosemide
• Gold Sodium Thiomalate
• Ciprofloxacin
• Doxycycline
• Levothyroxine
• Alendronate