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The use of estrogen medications, either alone or in combination with progestin, can pose significant health risks. It is crucial to have an informed discussion with your healthcare provider about the potential benefits and risks associated with hormone therapy. Estrogen treatments should not be used to prevent heart disease or dementia. Below are important safety considerations and warnings regarding the use of estrogen therapies:

• Cancer Risks:

  • Estrogen can increase the risk of uterine (endometrial) cancer, particularly if used without progestin in individuals with a uterus. Report any unusual vaginal bleeding to your healthcare provider immediately.
  • The combination of estrogen and progestin may elevate the risk of breast and ovarian cancer, especially with prolonged use. Regular breast exams and self-checks are advised.

• Blood Clots and Stroke:

  • Estrogen use can heighten the risk of developing blood clots, which may lead to serious conditions such as stroke or pulmonary embolism. If you are scheduled for surgery or prolonged bed rest, discuss discontinuing estrogen with your healthcare provider to reduce this risk. Seek emergency medical attention for symptoms like leg pain, chest pain, or sudden vision changes.

• Heart Disease:

  • Estrogen therapies should not be used to lower heart disease risk, as they may increase the likelihood of heart attacks. Emergency help should be sought for chest pain, difficulty breathing, or other heart attack symptoms.

• Dementia:

  • Postmenopausal women aged 65 and older using estrogen may have an increased risk of dementia. Consultation with your doctor is recommended if you are concerned about memory changes.

• Gallbladder and Liver Issues:

  • There is a risk of gallbladder problems and liver issues with estrogen use. Report persistent abdominal pain, jaundice, or nausea to your healthcare provider.

• Vision Problems:

  • Estrogen can cause retinal vascular thrombosis. Discontinue use and contact your doctor if you experience sudden vision loss or other eye symptoms.

• Triglycerides and Thyroid Levels:

  • Estrogen can elevate triglyceride levels, potentially leading to pancreatitis or heart problems. Regular monitoring may be necessary.
  • Those on thyroid hormone therapy may require dose adjustments. Regular thyroid level checks are advised.

• Fluid Retention:

  • Estrogens can cause fluid retention, which may exacerbate heart or kidney conditions. Notify your doctor if you experience significant swelling or rapid weight gain.

• Calcium Levels:

  • High calcium levels could occur in individuals with certain cancers. Symptoms such as thirst, bone pain, or confusion should be reported immediately.

• Worsening of Existing Conditions:

  • Estrogen may aggravate conditions like asthma, diabetes, or endometriosis. Discuss any pre-existing health issues with your doctor before starting treatment.

Contraindications: Estrogen therapy should not be used in individuals with the following conditions: unexplained vaginal bleeding, a history of breast cancer, estrogen-dependent cancers, blood clotting disorders, history of stroke or heart attack, liver problems, or during pregnancy.

Consult your healthcare provider to ensure this medication is appropriate for you and to discuss any concerns you may have regarding its use.

When using this medication, some individuals may experience common side effects such as breast tenderness, nausea, vomiting, headaches, migraines, stomach cramps, bloating, and weight changes. Vaginal spotting or breakthrough bleeding and mood changes may also occur. These side effects are generally mild, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

There are also other side effects that some users have reported, including dizziness, high blood pressure, eye problems, increased vaginal discharge, and nipple pain. While these are less common, it's important to monitor your symptoms and contact your healthcare provider if they become concerning.

Serious side effects, although rare, require immediate medical attention. These include symptoms of a heart attack, such as chest pain or tightness, shortness of breath, sweating, and pain radiating to the shoulder, arm, neck, or jaw. Signs of a stroke, like trouble talking or walking, numbness on one side of the body, severe headache, and confusion, also necessitate urgent care. Additionally, if you experience symptoms of a blood clot such as chest pain, fast heart rate, or swelling in the limbs, seek medical help promptly. Be vigilant for cancer-related symptoms like breast lumps, swollen lymph nodes, unusual vaginal bleeding, bloating, extreme fatigue, or abdominal pain.

An allergic reaction to this medication is very rare, but if you notice a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing, get medical assistance immediately. Always keep an eye on your health and report any side effects to your healthcare provider to ensure your safety.

Menest (esterified estrogens) can interact with certain medications and supplements. It is crucial to inform your healthcare provider and pharmacist about all the medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Some drugs should not be used with Menest due to potential interactions. These include dasabuvir, ombitasvir, paritaprevir, ritonavir, and tranexamic acid, as they can alter how Menest works or increase the risk of side effects. Your doctor might choose different treatment options if you are taking any of these.

There are also medications where the use with Menest is generally not recommended unless necessary. In such cases, your healthcare provider may adjust the dosages or frequency of your medications. These include a wide range of drugs, such as abametapir, amifampridine, various antibiotics like amoxicillin and ampicillin, and other medications including carbamazepine, dexamethasone, fosamprenavir, and St John's Wort, among others.

Additionally, Menest may affect the results of certain laboratory tests, such as the metyrapone test, potentially leading to false outcomes. Ensure that all laboratory personnel and your healthcare providers are aware that you are using this medication.