Prempro

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This medication includes two hormones: estrogen and a progestin. Some versions may use progesterone instead of a progestin. Both progesterone and progestin mimic the natural hormone progesterone produced by the body. This treatment is intended for women to alleviate menopause symptoms like hot flashes and vaginal dryness, which occur due to decreased estrogen levels. The progestin or progesterone component helps lower the risk of uterine cancer that can be associated with estrogen use. Women who have had their uterus removed do not need the progestin or progesterone and should avoid this combined medication. For treating symptoms limited to the vaginal area, consider using products applied directly inside the vagina before opting for oral, skin-absorbed, or injected medications. This medication may also be used post-menopause to prevent osteoporosis, but alternatives like raloxifene and bisphosphonates (e.g., alendronate) are available and might be safer. These alternatives should be considered before opting for estrogen/progestin treatment.
Our Prempro coupons are free to use. You can print the coupon, email it to yourself, or receive the Prempro coupon via text message. To get your free discount, show the pharmacist your Prempro savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Prempro prices will update based on your prescription needs. Above our Prempro coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Prempro savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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0.3-1.5MG, Prempro (30 Tablets)

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CVS

$256.81

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$255.24

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$256.39

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$267.38

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$256.81

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Prempro dosage forms

The average cost for 30 Tablets of Prempro at 0.625-2.5MG is $252.45 with a free coupon. This is 27.17% off the average retail price of $929.03
DosageQuantityPrice fromPer unit
0.625-2.5MG30 Tablets$252.45$8.41
0.625-5MG30 Tablets$111.02$3.7
0.45-1.5MG30 Tablets$252.48$8.42
0.3-1.5MG30 Tablets$252.51$8.42

Warnings

Estrogens, whether taken alone or combined with a progestin, can occasionally lead to severe side effects. It is crucial to evaluate the potential risks and rewards of hormone therapy with your healthcare provider. It is important to note that estrogens and progestins are not intended for the prevention of heart disease or dementia.

  • In women who have undergone menopause, the use of estrogen alongside a progestin may elevate the risk of cardiovascular issues, such as heart attacks and strokes, as well as serious blood clots in the lungs or legs, dementia, and certain types of cancer including breast and ovarian cancer.
  • The likelihood of encountering these serious side effects can vary based on the estrogen dosage and the duration of its use. Therefore, it is advised to administer the lowest effective dose for the shortest possible period.
  • Regular consultations with your doctor, ideally every 3 to 6 months, are recommended to assess the necessity of continued use of this medication.
  • For those on long-term treatment, annual comprehensive physical examinations should be conducted as advised by your healthcare provider.

By following these guidelines, you can help manage any potential risks associated with hormone therapy.

Prempro Side Effects

You may experience mild side effects such as stomach upset, nausea, vomiting, bloating, breast tenderness, headache, or changes in weight. These are generally not serious but should be discussed with your healthcare provider if they persist or worsen. It is important to note that many individuals taking this medication do not encounter severe side effects.

However, there are more serious side effects that require immediate attention. If you experience persistent nausea or vomiting, changes in mood or mental state like depression or memory loss, breast lumps, unusual vaginal bleeding, increased vaginal irritation, severe abdominal pain, yellowing of the skin or eyes, dark urine, swelling of the hands, ankles, or feet, or increased thirst or urination, contact your healthcare provider immediately.

In rare instances, this medication may lead to serious blood clot issues, potentially resulting in a heart attack, stroke, or clots in the lungs or legs. Seek emergency medical help if you experience chest pain, unusual sweating, sudden severe headaches, weakness on one side of the body, confusion, trouble speaking, sudden vision changes, or pain and swelling in the groin or calf, as well as shortness of breath, rapid breathing, sudden dizziness, or fainting.

Although a severe allergic reaction to this drug is rare, it is critical to seek urgent medical attention if you notice symptoms such as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing. This summary does not include all possible side effects. If you notice any other unusual symptoms, consult your healthcare provider.

Interactions

Some drugs that can interact with this medication include aromatase inhibitors like Anastrozole, Exemestane, and Letrozole; fezolinetant; Fulvestrant; ospemifene; Raloxifene; Tamoxifen; Toremifene; and Tranexamic Acid. Additionally, certain combination treatments for chronic hepatitis C, such as ombitasvir/paritaprevir/ritonavir with or without dasabuvir, may also interact. This medicine might affect the results of specific lab tests, like the metyrapone test, leading to inaccurate outcomes. Ensure that all laboratory staff and your healthcare providers are aware that you are taking this medication.
Prempro FAQs
Does Prempro cause weight gain?

Prempro, a hormone replacement therapy, may cause weight gain as a side effect in some individuals. However, weight gain can vary from person to person and may be influenced by other factors such as diet, lifestyle, and individual metabolism. It is important for individuals to discuss any concerns about side effects with their healthcare provider.

Prempro should not be taken by individuals who have a history of breast cancer, estrogen-dependent tumors, or unexplained vaginal bleeding. It is also contraindicated in those with active or past history of blood clots, liver disease, or known hypersensitivity to any of its components. Additionally, it should not be used by pregnant women or those with a known or suspected pregnancy. It is important for individuals to consult with their healthcare provider to determine if Prempro is appropriate for their specific health conditions.

Hormone replacement therapy (HRT) is generally not recommended for individuals with certain conditions. These include those with a history of breast cancer, endometrial cancer, unexplained vaginal bleeding, active or recent blood clots, liver disease, or a history of heart disease or stroke. Additionally, individuals who are pregnant or have a known allergy to any component of the therapy should avoid HRT. It is important for individuals to consult with their healthcare provider to evaluate their specific health conditions and risks before starting HRT.

Weight changes can occur with the use of Prempro, as some individuals may experience weight gain while others might not notice any significant change. It is important to monitor any changes in weight and discuss them with a healthcare provider to determine the best course of action.

Prempro is a medication that combines conjugated estrogens and medroxyprogesterone acetate. It is primarily used for hormone replacement therapy in postmenopausal women. Prempro helps alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention. It works by supplementing the body with estrogen and progestin, which decrease during menopause.