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When considering hormone therapy, it's essential to weigh the potential risks and benefits with your healthcare provider. Estrogens, either alone or combined with a progestin, have been associated with rare but severe side effects. It is important to note that estrogens and progestins are not recommended for the prevention of heart disease or dementia.

• In postmenopausal women, using estrogen with a progestin may elevate the risk of heart disease, including heart attacks, strokes, serious blood clots in the lungs or legs, dementia, and breast or ovarian cancer.
• The likelihood of experiencing serious side effects may be influenced by the dosage of estrogen and the duration of use.
• To minimize risks, use this medication at the lowest effective dose and for the shortest period necessary.
• Regular consultations with your healthcare provider are crucial; consider discussing the need for continued use every 3 to 6 months.
• If long-term use is anticipated, schedule comprehensive physical examinations annually or as advised by your doctor.

Experiencing stomach upset, nausea, vomiting, bloating, breast tenderness, headaches, or weight changes can be common when taking this medication. These side effects are generally mild and should improve over time. However, if they persist or worsen, it's important to seek medical advice.

In some cases, more serious side effects can occur. If you experience persistent nausea or vomiting, changes in mood or memory, breast lumps, unusual vaginal bleeding, increased vaginal irritation, severe abdominal pain, yellowing of the eyes or skin, dark urine, swelling of the hands, ankles, or feet, or increased thirst and urination, contact your healthcare provider promptly.

Rarely, this medication can lead to serious blood clot-related conditions, which can be life-threatening. Seek immediate medical attention if you experience chest pain, unusual sweating, severe headaches, weakness on one side of the body, confusion, trouble speaking, sudden vision changes, pain or swelling in the calf or groin, difficulty breathing, or sudden dizziness or fainting.

Allergic reactions to this medication are very rare but can be serious. If you notice signs of an allergic reaction, such as a rash, swelling, severe dizziness, or difficulty breathing, get emergency medical help immediately. Always report any side effects you experience to your healthcare provider. This summary does not include all possible side effects. If you have any concerns about side effects not listed here, consult your healthcare provider for further guidance.