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When considering the use of estrogen or estrogen/progestin therapies, it is crucial to be aware of certain risks and precautions. Below is a summary of important safety information to discuss with your healthcare provider:

• Potential Serious Side Effects: These medications may rarely cause severe side effects. It is important to weigh the risks and benefits with your doctor. Estrogens and progestins should not be used to prevent heart disease or dementia.

• Cardiovascular Risks: Estrogen and estrogen/progestin therapies can increase the likelihood of developing blood clots, heart attacks, and strokes. This risk is heightened for individuals with a personal or family history of blood clots, high blood pressure, diabetes, high cholesterol, tobacco use, obesity, or systemic lupus erythematosus (SLE).

• Cancer Risks: The use of these therapies can elevate the risk of breast, uterine/endometrial, and ovarian cancers. Regular breast examinations and mammograms are recommended. Individuals with a history of estrogen-sensitive cancers should avoid these therapies.

• Dementia: There is an increased risk of dementia associated with hormone therapy, particularly if initiated after age 65. These therapies should not be used for dementia prevention.

• Liver and Gallbladder Issues: Estrogen therapy can exacerbate liver problems or lead to gallbladder disease. Notify your healthcare provider if you have a history of jaundice or liver disease.

• Calcium Imbalance: Estrogen can alter blood calcium levels, potentially causing fatigue, muscle weakness, nausea, or constipation, especially in individuals with breast cancer that has spread to the bones.

• Vision Problems: Although rare, estrogens can cause vision issues due to clot formation in the eyes. If you experience sudden vision changes, seek medical attention promptly.

• Triglyceride Levels: Estrogen therapy might increase blood triglyceride levels, potentially leading to pancreatitis. Regular blood tests may be necessary to monitor this effect.

• Thyroid and Fluid Retention: Estrogen can affect thyroid hormone levels and cause fluid retention, which may worsen conditions like heart failure or kidney damage. Regular monitoring and adjustments in thyroid medication dosage may be required.

• Worsening of Pre-existing Conditions: Conditions such as high blood pressure, asthma, diabetes, migraines, and seizures may be aggravated by estrogen therapy. Provide your complete medical history to your healthcare provider before starting treatment.

• Contraindications: Do not use these medications if you have undiagnosed abnormal vaginal bleeding, a history of breast cancer or other estrogen-sensitive tumors, blood clots, heart attack, stroke, liver disease, or specific blood clotting conditions.

In case of overdose or severe side effects, seek immediate medical attention. Discuss any concerns or questions with your healthcare provider to ensure safe and effective use of these therapies.

When taking this medication, some individuals may experience mild side effects, which are generally manageable. Common side effects include breast tenderness, headaches, weight changes, stomach upset, nausea, and bloating. You might also experience postmenopausal bleeding, mood swings, back pain, or symptoms of upper respiratory tract infections like a cough or sore throat. If these effects persist or worsen, it's advisable to consult your healthcare provider for guidance.

Other side effects can include changes in vaginal bleeding patterns such as spotting or breakthrough bleeding, as well as stomach pain, gas, bloating, and diarrhea. Some might notice fatigue, dizziness, nervousness, sleep disturbances, or changes in appetite, sex drive, or hair growth. Swelling in the arms, legs, or feet and shifts in weight are also reported by some users.

Serious side effects, although rare, require immediate medical attention. These include symptoms of blood clots, such as trouble breathing, leg pain, or swelling. Signs of a heart attack, like chest or arm pain and shortness of breath, and symptoms of a stroke, such as sudden weakness on one side of the body or changes in speech, are critical. High or low calcium levels, indicated by muscle weakness or spasms, nausea, or tingling sensations, should also be promptly addressed. Additionally, unusual vaginal bleeding or discharge and pelvic pain warrant urgent medical care.

While allergic reactions are uncommon, they can occur. Seek immediate medical help if you experience symptoms like a rash, severe dizziness, swelling of the face or throat, or difficulty breathing. Always contact your healthcare provider if you notice any side effects not listed here.

When using Mimvey (Estradiol / Norethindrone), it is important to be aware of potential interactions with other medications. Inform your doctor and pharmacist about all medications and supplements you are currently taking, including prescription, over-the-counter, vitamins, and herbal supplements. Some medicines may not be recommended for use with Mimvey, such as boceprevir, Cyclosporine, dasabuvir, eltrombopag, Gemfibrozil, ombitasvir, paritaprevir, Ritonavir, and Tranexamic Acid, as these could lead to adverse effects or alter the effectiveness of treatment.

Additionally, there are medications that may be used with caution alongside Mimvey, with possible adjustments in dosage or frequency, including Amiodarone, Alprazolam, Amoxicillin, and many others. Your healthcare provider will determine if these combinations are necessary and how to manage them.

Furthermore, Mimvey may affect the results of certain laboratory tests, such as the metyrapone test, which could result in inaccurate outcomes. Ensure that all healthcare providers and laboratory personnel are informed that you are using this medication to prevent misinterpretation of test results.