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Divigel should be applied to clean, dry, and unbroken skin on the upper thigh. It is important to alternate the application site between the left and right thigh each day to avoid irritation. The gel should not be applied to the breasts or any other area of the body.

The best places to apply estrogen gel are typically the upper arms, shoulders, or inner thighs. It is important to apply the gel to clean, dry, and unbroken skin. The gel should be spread evenly over the area and allowed to dry completely before dressing. It is also advisable to avoid applying the gel to the breasts or any areas that may be exposed to sunlight.

Estradiol is a form of estrogen, a female hormone involved in various bodily functions. Divigel, on the other hand, is a brand name for a topical gel that contains estradiol. The primary difference is that estradiol refers to the hormone itself, while Divigel is a specific formulation used to deliver estradiol through the skin for hormone replacement therapy.

Divigel is used for the treatment of moderate to severe vasomotor symptoms associated with menopause, such as hot flashes. It is a form of estrogen therapy applied topically to the skin.

Divigel, which is a form of estrogen therapy, may start to show effects within a few weeks. However, the time it takes to notice improvements can vary depending on the individual and the symptoms being treated. Some may experience relief from symptoms such as hot flashes within a few weeks, while others might take longer. It is important for patients to follow their healthcare provider's instructions and discuss any concerns or lack of improvement with them.