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Estradiol

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estradiol

This medication is a hormone (estrogen). It is absorbed through the skin and enters into the bloodstream. It is used by women to help reduce a certain symptom of menopause (hot flashes). Symptoms of menopause are caused by the body making less estrogen. If you are using estrogens to treat only vaginal symptoms of menopause (such as vaginal dryness/burning/itching), products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Our coupons are free to use. You can print the coupon, email it to yourself, or receive the coupon via text message. To get your free discount, show the pharmacist your savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The prices will update based on your prescription needs. Above our coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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0.25MG/0.25GM, Estradiol (30 Gels)

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CVS

$32.58

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Walgreens

$47.32

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Rite Aid

$62.05

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Walmart

$94.74

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Estradiol savings card

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$32.58

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Estradiol dosage forms

The average cost for 30 Gels of Estradiol (estradiol) at 0.25MG/0.25GM is $32.46 with a free coupon. This is 17.12% off the average retail price of $189.6
DosageQuantityPrice fromPer unit
0.25MG/0.25GM30 Gels$32.46$1.08
0.5MG/0.5GM30 Gels$32.46$1.08
0.75MG/0.75GM30 Gels$32.46$1.08

Warnings

Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks). The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. This medication should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of this medication with your doctor regularly (for example, every 3 to 6 months) to see if you still need to use it. If you will be taking this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor.

Estradiol Side Effects

Nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach/abdominal pain, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination. This medication may rarely cause serious (sometimes fatal) problems from blood clots (such as heart attack, stroke, blood clots in the lungs or legs). Get medical help right away if you have: chest/jaw/left arm pain, unusual sweating, sudden/severe headaches, weakness on one side of the body, confusion, trouble speaking, sudden vision changes, pain/swelling/warmth in the groin/calf, shortness of breath/rapid breathing, sudden dizziness/fainting. A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug include: aromatase inhibitors (such as anastrozole, exemestane, letrozole), fezolinetant, fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid. This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Estradiol FAQs
Where is the best place to apply Divigel?

Divigel should be applied to clean, dry, and unbroken skin on the upper thigh. It is important to alternate the application site between the left and right thigh each day to avoid irritation. The gel should not be applied to the breasts or any other area of the body.

The best places to apply estrogen gel are typically the upper arms, shoulders, or inner thighs. It is important to apply the gel to clean, dry, and unbroken skin. The gel should be spread evenly over the area and allowed to dry completely before dressing. It is also advisable to avoid applying the gel to the breasts or any areas that may be exposed to sunlight.

Estradiol is a form of estrogen, a female hormone involved in various bodily functions. Divigel, on the other hand, is a brand name for a topical gel that contains estradiol. The primary difference is that estradiol refers to the hormone itself, while Divigel is a specific formulation used to deliver estradiol through the skin for hormone replacement therapy.

Divigel is used for the treatment of moderate to severe vasomotor symptoms associated with menopause, such as hot flashes. It is a form of estrogen therapy applied topically to the skin.

Divigel, which is a form of estrogen therapy, may start to show effects within a few weeks. However, the time it takes to notice improvements can vary depending on the individual and the symptoms being treated. Some may experience relief from symptoms such as hot flashes within a few weeks, while others might take longer. It is important for patients to follow their healthcare provider's instructions and discuss any concerns or lack of improvement with them.