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When using this medication for psoriasis treatment, it is essential to reserve its use for severe cases that have not improved with other therapies, due to the potential for serious side effects like cataracts or skin cancer. Please consult your healthcare provider for additional information.

Important points to consider include:

• The medication is available in various dosage forms, each with distinct effects. It is crucial to avoid switching between these forms without medical guidance.
• Upon receiving a refill, verify that you have been given the correct form as prescribed by your doctor.

Always follow your healthcare professional's advice to ensure safe and effective use of this medication.

Common side effects:

• Nausea
• Difficulty sleeping
• Mild itching
• Drying of the skin
• Reddening of the skin
• Darkening of the skin

Less common but important to monitor:

• Significant reddening of the skin
• Blistering of the skin
• Peeling of the skin
• Burning of the skin
• Thinning of the skin
• Wrinkling of the skin
• Painful changes in nail color
• Unusual growths, moles, or skin sores
• Swelling of the ankles
• Changes in mental or mood states
• Vision changes

Serious side effects:

• Severe allergic reaction
• Rash
• Severe itching or swelling, particularly of the face, tongue, or throat
• Extreme dizziness
• Difficulty breathing

Methoxsalen, a medication used to treat certain skin conditions, can interact with various substances, potentially affecting its effectiveness and safety. It's important to be aware of these interactions to manage your treatment properly.

Drug Interactions:

• Photosensitizing Agents: Combining methoxsalen with other medications that increase skin sensitivity to light can heighten the risk of severe sunburns. Such medications include:

  • Phenothiazines (e.g., Chlorpromazine, Prochlorperazine)
  • Sulfonamides (e.g., Sulfadiazine, Sulfamethoxazole)
  • Sulfonylureas (e.g., Glimepiride, Glipizide)
  • Tetracyclines (e.g., doxycycline, Minocycline)
  • Fluoroquinolone antibiotics (e.g., Ciprofloxacin, Levofloxacin)
  • Thiazide diuretics (e.g., Hydrochlorothiazide, Chlorthalidone)
  • Griseofulvin, an antifungal medication
  • Coal tar products used for skin conditions
  • Anthralin, used for psoriasis treatment

  Using methoxsalen alongside these drugs may lead to increased photosensitivity. It's advisable to consult your healthcare provider about the necessity of adjusting your medication regimen.

• CYP1A2 Inhibitors: Methoxsalen can inhibit the enzyme CYP1A2, affecting the metabolism of certain drugs. This interaction may increase the levels of medications metabolized by this enzyme, such as:

  • Bendamustine, a chemotherapy agent
  • Tasimelteon, used for sleep disorders
  • Tazemetostat, a cancer treatment
  • Terbinafine, an antifungal medication

  If you're taking any of these medications, inform your doctor to determine if dosage adjustments are necessary.

Food Interactions:

• Furocoumarin-Containing Foods: Certain foods contain natural compounds called furocoumarins, which can increase skin sensitivity to light. While undergoing treatment with methoxsalen, it's recommended to avoid:

  • Limes
  • Figs
  • Parsley
  • Parsnips
  • Celery
  • Carrots
  • Mustard

  Contact with these foods can further sensitize your skin, increasing the risk of sunburn.

Alcohol Interaction:

• The effects of alcohol on methoxsalen are not well established. It's advisable to consult your healthcare provider regarding alcohol consumption during your treatment.

General Recommendations:

• Sun Exposure: Methoxsalen increases skin sensitivity to sunlight. After taking the medication, avoid sun exposure for at least 24 hours. If you must go outside, wear protective clothing, use a broad-spectrum sunscreen with an SPF of 15 or higher, and wear UVA-absorbing sunglasses to protect your eyes.

• Medication Disclosure: Always inform your healthcare provider about all medications, supplements, and herbal products you're currently using. This information helps in assessing potential interactions and ensuring safe and effective treatment.

By being aware of these interactions and following your healthcare provider's guidance, you can minimize risks and maximize the benefits of methoxsalen therapy.