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This medication carries significant risks and requires careful adherence to safety guidelines. Below are important precautions and instructions for its use:

• Pregnancy Risks: This drug can cause severe birth defects. Do not use if you are pregnant or planning to become pregnant within three years of stopping the treatment. Women of childbearing potential must use two forms of effective contraception starting one month before treatment, during treatment, and for at least three years after discontinuation. Avoid alcohol during treatment and for two months after stopping, as it can prolong the drug's presence in the body. Monthly pregnancy tests are mandatory during treatment and every three months for three years after stopping.

• Male Patients: Small amounts of the drug may be present in semen. Discuss potential risks with your healthcare provider if you have concerns about fathering a child.

• Blood Donation: Do not donate blood during treatment and for at least three years after stopping, as the drug can harm an unborn child if transfused to a pregnant recipient.

• Liver Health: This medication can seriously affect liver function. Monitor liver health through regular blood tests. Consult your healthcare provider if you experience severe nausea, vomiting, jaundice, loss of appetite, or dark urine.

• Cholesterol and Pancreatitis: The drug may increase cholesterol and triglyceride levels, raising heart disease risk. Pancreatitis has also been reported. Regular blood tests are necessary. Seek emergency help if you experience chest pain, arm pain, shortness of breath, cold sweat, or speech difficulties.

• Skeletal Changes: Long-term use can cause changes in the spine, knees, and ankles. Contact your healthcare provider if you have mobility issues.

• Vision Changes: This medication can cause visual disturbances, including dry eyes, which may affect contact lens wearers. Report any vision issues to your healthcare provider immediately.

• Increased Brain Pressure: Avoid using tetracyclines concurrently, as both drugs can elevate brain pressure. Be alert for severe headaches, vision changes, and persistent nausea or vomiting.

• Capillary Leak Syndrome: Though rare, this condition can occur. Symptoms include swelling, weight gain, fever, and low blood pressure. Report these symptoms to your healthcare provider without delay.

• Severe Skin Reactions: Instances of severe skin peeling have been reported. Discontinue use and seek medical advice if this occurs.

Contraindications: Do not use this medication if you have severe liver or kidney disease, high blood lipid values, or are allergic to retinoids. Avoid concurrent use with methotrexate or tetracycline antibiotics. Always consult your healthcare provider for personalized advice and before starting or stopping any medication.

When taking this medication, you may experience some common side effects as your body adjusts. These include chapped lips, skin peeling, hair loss, itching or scaly skin, and runny nose. You might also notice dry eyes, dry mouth, or changes in your nails. Contact lens wearers might feel discomfort due to dry eyes. While these effects are usually mild, if they persist or worsen, consult your healthcare provider.

Other side effects that could occur include tiredness, trouble sleeping, mood changes, appetite changes, headaches, flushing, vision changes, nausea, or diarrhea. These symptoms are generally not severe, but it's important to monitor them and seek advice if necessary.

Serious side effects, though rare, require immediate medical attention. These include signs of an allergic reaction such as hives, swelling of the face or tongue, and breathing difficulties. Other severe symptoms include sudden weight gain, fever, low blood pressure, severe headaches, vision loss, depression, symptoms of heart issues like chest pain, or signs of liver problems like yellowing skin and dark urine. High blood sugar levels and capillary leak syndrome are also serious concerns.

If you encounter any of these severe side effects, seek urgent medical care. Always be attentive to how your body responds to the medication and consult your healthcare provider with any concerns.

Acitretin can interact with several medications and supplements. It is important to inform your doctor and pharmacist about all the drugs and supplements you are taking, including prescription and over-the-counter medications, vitamins, and herbal products. Some products that may interact with Acitretin include methotrexate, St. John's wort, and vitamin A.

Additionally, Acitretin should not be used with tetracycline antibiotics such as Chlortetracycline, Demeclocycline, Doxycycline, and others in this category. This combination is not recommended because it could lead to increased side effects or reduced effectiveness. In some cases, your doctor may choose to prescribe both, but adjustments to dosages or frequency might be necessary.

Furthermore, combining Acitretin with Pexidartinib is usually not advised, though there may be situations where both are required. If so, your healthcare provider might modify how you take these medications.

Lastly, using Acitretin with Levonorgestrel may increase the risk of certain side effects, yet it might be the best treatment option. In such cases, your doctor will carefully adjust your medication regimen to balance benefits and risks.