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The safety and warning information for nitroglycerin ER (Nitro-Time) includes crucial details that you should be aware of to ensure proper use and minimize risks. Always consult with your healthcare provider if you have any questions or concerns.

• Tolerance: Over time, your body may become accustomed to the effects of nitroglycerin ER (Nitro-Time), a condition known as tolerance or tachyphylaxis. This is more likely if you have been using other long-acting nitrates (e.g., isosorbide mononitrate or isosorbide dinitrate). Increasing the dosage will not improve the medication's effectiveness. Adhere strictly to the prescribed dosage and inform your healthcare provider if you experience worsening chest pain. To prevent tolerance, your doctor may advise a nitrate-free interval of 10-12 hours daily.

• Low Blood Pressure: This medication can significantly lower blood pressure, leading to dizziness, fatigue, or lightheadedness. It is important to sit down for the first few minutes after taking the medication to avoid fainting. Change positions slowly to allow your body to adjust. Seek emergency assistance if you experience symptoms such as fainting, irregular heartbeat, nausea, vomiting, weakness, vision changes, sweating, cold or clammy skin, or worsening chest pain. The risk increases with dehydration, use of erectile dysfunction or blood pressure medications, and alcohol consumption.

• Worsening Chest Pain: In rare instances, nitroglycerin ER (Nitro-Time) may exacerbate chest pain related to hypertrophic cardiomyopathy, a condition where the heart muscles are unusually thick. If you have this condition, confirm with your healthcare provider that this medication is suitable for you. Seek immediate medical help if your chest pain worsens after taking the medication.

• Headache: Some users may experience headaches, particularly when changing positions from sitting or lying down to standing. These headaches typically diminish as your body adjusts to the medication. If they persist or are bothersome, discuss alternative options with your healthcare professional. The likelihood of headaches increases when first starting the medication, with higher doses, or with alcohol use.

• Contraindications: Do not use nitroglycerin ER (Nitro-Time) if you have an allergy to other nitrates such as isosorbide mononitrate or isosorbide dinitrate. Always consult your healthcare provider before starting this medication if this applies to you.

Following these guidelines will help ensure safe and effective use of nitroglycerin ER (Nitro-Time).

When taking this medication, you might experience some common side effects as your body adjusts. These can include headaches, dizziness, lightheadedness, nausea, and flushing. Headaches are often a sign that the medication is working. If they persist or worsen, consider using an over-the-counter pain reliever such as acetaminophen or aspirin, but consult your healthcare provider if the headaches become severe. To help minimize dizziness and lightheadedness, it is advisable to rise slowly from sitting or lying positions.

While most people do not experience serious side effects, it is important to be aware of them. Serious side effects can include fainting and an irregular or pounding heartbeat. If you notice these symptoms, contact your healthcare provider immediately. Though rare, a very serious allergic reaction may occur. Seek urgent medical attention if you experience symptoms such as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing.

If you encounter any other effects not listed here, or if you have concerns about any side effects, reach out to your healthcare provider for guidance. Remember, while side effects can be concerning, the benefits of the medication, as determined by your healthcare provider, generally outweigh these risks.

Nitroglycerin ER (Nitro-Time) has the potential to interact with certain medications. It's crucial to inform your healthcare provider and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter drugs, vitamins, and herbal products.

The use of Nitroglycerin ER with medications such as Avanafil, Riociguat, Sildenafil, Tadalafil, and Vardenafil is generally not recommended due to significant interactions. These medications, used for erectile dysfunction or pulmonary hypertension, can cause serious side effects if combined with Nitroglycerin ER.

Additionally, combining Nitroglycerin ER with Alteplase, Recombinant may typically be avoided unless necessary. In such cases, your doctor might adjust the dosages or frequency of use to mitigate risks.

Other medications, like Acetylcysteine, Apomorphine, Aspirin, Dihydroergotamine, and Pancuronium, may increase the risk of side effects when used with Nitroglycerin ER, yet both might be required for optimal treatment. Your healthcare provider may need to adjust how you use these medications together.

Furthermore, Nitroglycerin ER can affect certain laboratory test results, such as blood cholesterol levels, leading to inaccurate outcomes. Ensure all your doctors and lab personnel are aware of your use of this medication.