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This safety information outlines critical warnings regarding the use of isosorbide dinitrate (Isordil). Please read these details carefully and consult with your healthcare provider if you have any questions or concerns.

• Low Blood Pressure Risks: Isosorbide dinitrate can significantly lower your blood pressure, particularly when taken with erectile dysfunction medications or alcohol. This could lead to life-threatening conditions. Seek immediate medical attention if you experience symptoms such as feeling faint, irregular heartbeat, nausea, vomiting, blurred vision, excessive sweating, or cold, clammy skin. Some individuals may feel dizzy or faint when changing positions quickly, such as moving from sitting to standing. To reduce these effects, change positions gradually until your body adjusts to the medication. Contact your healthcare provider if dizziness or rapid heart rate persists a week after starting treatment. Those at higher risk include individuals over 65 years of age, users of erectile dysfunction medications, and those who consume alcohol.

• Development of Tolerance: Over time, your body may develop a tolerance to isosorbide dinitrate, reducing its effectiveness. This occurs more frequently if doses are not taken as scheduled. It is crucial to adhere strictly to your healthcare provider's dosing instructions. If you notice worsening chest pain, consult your provider. Increasing the medication dose will not overcome tolerance. Long-term users are particularly at risk.

Please make sure to follow your healthcare provider's guidance and report any adverse effects promptly.

When taking this medication, some common side effects may occur. These include headaches and dizziness, which are generally mild. If these symptoms persist or worsen, consulting a healthcare provider is advisable for reassurance and guidance.

Other side effects that have been reported include low blood pressure and fainting. While these effects are less common, it's important to be cautious. If you experience them, especially if they become severe, it's recommended to contact a healthcare provider for advice.

There are also rare but serious side effects associated with this medication that require immediate medical attention. These include feeling faint, particularly when standing, experiencing a slowed or irregular heartbeat, and any changes in vision such as blurriness. Additionally, confusion is a serious symptom that should prompt seeking urgent medical care. Always prioritize safety and seek help if these serious symptoms appear.