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Clobazam is a medication associated with several important safety considerations. It is crucial to use this drug responsibly and be aware of the potential risks, especially when combined with other substances. Below are key safety points and warnings to consider:

• Risk of Abuse and Addiction: Clobazam has the potential for misuse that may lead to addiction and overdose, possibly resulting in death. It is classified as a controlled substance. Misuse increases the risk of severe side effects, including memory issues, confusion, and muscle pain, as well as life-threatening breathing problems.

• Severe Interactions with Opioids: Using clobazam together with opioids can lead to extreme drowsiness, dangerously slow breathing, coma, or death. These medications should only be combined if absolutely necessary, and your healthcare provider should prescribe the lowest effective dose for the shortest duration.

• Withdrawal Symptoms: Abruptly discontinuing clobazam can cause serious withdrawal symptoms, which might include headaches, insomnia, restlessness, hallucinations, confusion, and seizures. To minimize withdrawal risks, your healthcare provider may gradually reduce your dose.

• Drowsiness and Impaired Concentration: Clobazam can cause significant drowsiness and affect your ability to concentrate and react. The risk is higher if you are also taking other sedative medications. Assess how clobazam affects you before engaging in activities that require alertness, such as driving.

• Serious Skin Reactions: There is a risk of life-threatening skin conditions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Be vigilant for symptoms such as fever, sore throat, rash, blisters, or facial swelling, and seek medical help immediately if they occur.

• Suicidal Thoughts and Behavior: Clobazam may increase the risk of suicidal thoughts or behaviors, which can arise within the first week of treatment and persist. Contact a healthcare provider immediately if you experience anxiety, panic attacks, or mood changes.

• Effects During Pregnancy: Taking clobazam in late pregnancy can result in adverse effects in newborns, such as respiratory issues and withdrawal symptoms. Discuss with your provider the risks and benefits of using clobazam during pregnancy and consider enrolling in the NAAED Pregnancy Registry to contribute to research on anti-seizure medications.

Always follow your healthcare provider’s instructions precisely, and consult them before making any changes to your medication regimen. Report any concerning symptoms or side effects to your provider promptly.

When taking this medication, some individuals may experience common side effects such as drowsiness, dizziness, tiredness, headache, constipation, weight gain, cough, drooling, trouble sleeping, nausea, and changes in appetite. These side effects are typically mild and may subside over time. However, if they persist or worsen, it is advisable to consult with a healthcare provider.

There are other side effects that, while less common, should still be monitored. These include fever, upper respiratory tract infections, low energy levels, vomiting, slurred speech, trouble swallowing, pain with urination, and problems with coordination. Again, if any of these symptoms become severe, it is important to seek medical advice.

Serious side effects, although rare, demand immediate medical attention. These include significant allergic and skin reactions such as fever, sore throat, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, and swollen lymph nodes. Severe symptoms like extreme sleepiness, dizziness, or any signs of suicidal behavior or thoughts of self-harm also require urgent care. Additionally, this medication may rarely cause very serious skin reactions, particularly in the early weeks of treatment or upon restarting the medication. If you experience any unusual or sudden changes in mood, thoughts, or behavior, or if you notice symptoms like memory loss, muscle weakness, vision changes, or trouble speaking, contact a healthcare professional immediately.

Though a severe allergic reaction to this medication is rare, it is critical to seek medical help if symptoms such as fever, swollen lymph nodes, rash, itching/swelling, severe dizziness, or trouble breathing occur. Always report any unexpected side effects to your healthcare provider.

Clobazam (Onfi) can interact with a variety of medications and supplements, so it's important to inform your doctor and pharmacist about everything you are taking, including prescription, over-the-counter drugs, vitamins, and herbal supplements.

Some drugs that should generally be avoided while using clobazam include flumazenil and thioridazine. If these are prescribed to you, your doctor may need to consider alternative treatments.

There are also medications that are typically not recommended to be used together with clobazam but might be necessary in certain situations. In such cases, your doctor might adjust the dosage or frequency of either medication. These include a wide range of drugs such as alprazolam, buprenorphine, codeine, hydrocodone, lorazepam, zolpidem, and muscle relaxants like carisoprodol and cyclobenzaprine, among others.

Combining clobazam with these medications can increase the risk of severe side effects such as drowsiness, dizziness, and respiratory issues. It is particularly important to be cautious if you are also consuming substances like alcohol, marijuana, or other medications that can cause drowsiness or breathing difficulties.

Furthermore, clobazam can reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, which could lead to pregnancy. It’s advisable to discuss with your doctor about using additional or alternative birth control methods. If you notice any unusual bleeding, it could indicate that your birth control is not working as it should.

Lastly, certain medications can affect how clobazam is processed in your body, potentially altering its effectiveness. Examples include fluconazole and fluvoxamine. If prescribed together, your doctor might modify the doses or how often you use these medications.

Always check with your healthcare provider or pharmacist before starting or stopping any medication while on clobazam to ensure safe and effective treatment.