Orilissa

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Orilissa (elagolix) is a medication designed to alleviate moderate to severe pain associated with endometriosis, a condition where tissue similar to the lining inside the uterus grows outside it, causing pain and other symptoms. This drug is part of a class known as gonadotropin-releasing hormone (GnRH) antagonists. It functions by blocking GnRH receptors in the brain, reducing the production of certain hormones, particularly estrogen, which are involved in endometriosis-related pain. By lowering these hormone levels, Orilissa helps reduce the discomfort caused by the condition. The medication is taken orally, typically once or twice daily. Common side effects may include hot flashes and headaches, and it can interact with other medications, such as birth control pills. It's crucial to consult a healthcare professional before starting Orilissa to ensure it's safe and suitable for your specific health needs.
Our Orilissa coupons are free to use. You can print the coupon, email it to yourself, or receive the Orilissa coupon via text message. To get your free discount, show the pharmacist your Orilissa savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Orilissa prices will update based on your prescription needs. Above our Orilissa coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Orilissa savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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150MG, Orilissa (30 Tablets)

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CVS

$1303.39

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$1328.53

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$1339.52

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Orilissa dosage forms

The average cost for 30 Tablets of Orilissa at 150MG is $1249.53 with a free coupon. This is 27.04% off the average retail price of $4621.87
DosageQuantityPrice fromPer unit
150MG30 Tablets$1249.53$41.65
200MG30 Tablets$623.27$20.78

Orilissa Warnings

The following safety and warning information outlines potential risks and precautions associated with the use of Orilissa (elagolix). It is crucial to understand these details and consult your healthcare provider with any questions or concerns.

  • Bone Loss: Orilissa (elagolix) can lead to a reduction in bone mineral density, which might not fully recover after discontinuation. This risk increases with higher doses and prolonged use. Individuals with a history of osteoporosis should avoid using this medication.

  • Menstrual Changes and Pregnancy Recognition: Users may experience lighter, shorter, or less frequent menstrual bleeding, which can complicate pregnancy detection. If pregnancy is suspected, take a test and cease using Orilissa (elagolix) if positive, informing your healthcare provider due to an increased risk of pregnancy loss if the drug is taken early in pregnancy.

  • Mental Health Concerns: There is an elevated risk of depression, mood changes, and suicidal thoughts or behaviors. Notify your healthcare team immediately if you experience new or worsening mental health symptoms. If suicidal thoughts occur, seek emergency assistance by calling 911.

  • Liver Health: Some users may experience elevated liver enzyme levels, indicating potential liver damage, especially at higher doses. Those with pre-existing liver issues should exercise caution.

  • Interactions with Hormonal Birth Control: Orilissa (elagolix) may reduce the effectiveness of hormonal birth control, particularly those containing progestin. The interaction with progestin-only methods is uncertain, so consider using non-hormonal contraceptives to prevent pregnancy.

  • Risk to Unborn Babies: This medication may increase the risk of pregnancy loss if taken during early pregnancy. Women of childbearing potential should confirm they're not pregnant before starting Orilissa (elagolix) and use effective non-hormonal contraception during treatment and for 28 days after the last dose.

Contraindications: Orilissa (elagolix) should not be used under the following conditions as it may lead to serious health risks:

  • Current pregnancy
  • Osteoporosis
  • Severe liver impairment
  • Concurrent use of certain medications that increase Orilissa (elagolix) levels in the body

Consult your healthcare provider if any of these conditions apply to you before starting this medication.

Orilissa Side Effects

When taking this medication, some common side effects may occur, but they are usually mild and manageable. These include hot flashes, headaches, nausea, trouble sleeping, and changes in menstrual cycles. Additionally, some people may experience mood swings, a depressed mood, anxiety, joint pain, and a lower sex drive. Occasionally, individuals might notice diarrhea, stomach pain, constipation, weight gain, dizziness, and irritability. If these effects persist or become bothersome, it is advisable to consult with a healthcare provider for guidance.

While most people do not experience severe side effects, there are some serious reactions that require immediate medical attention. These include signs of liver damage, such as yellowing of the skin or eyes, persistent nausea or vomiting, loss of appetite, dark urine, and abdominal pain. A very serious allergic reaction is rare but can occur, with symptoms like rash, swelling of the face, tongue, or throat, and difficulty breathing. Mental health changes, including new or worsening depression, anxiety, unusual behavior, or thoughts of suicide, are also serious and necessitate urgent care.

This medication can lower estrogen levels, potentially leading to bone loss, which may be permanent with prolonged use. Discuss with your healthcare provider the risks and benefits of this medication, and consider taking calcium and vitamin D supplements to support bone health. Always report any new or unlisted side effects to your healthcare provider for further advice.

Orilissa Interactions

Elagolix can interact with various medications, potentially impacting how it functions. Some drugs, such as asciminib, belumosudil, cyclosporine, encorafenib, gemfibrozil, letermovir, resmetirom, vadadustat, and voclosporin, might alter the elimination process of elagolix from your body. This change can influence elagolix's effectiveness. Additionally, elagolix may accelerate the removal of certain other medications, potentially altering their effects. Affected drugs include daridorexant, elacestrant, mavacamten, quizartinib, and revumenib.

Furthermore, hormonal birth control methods may interact with elagolix. Women who are of childbearing age should consult their healthcare provider to discuss alternative, reliable non-hormonal birth control options.

Orilissa FAQs
What does orilissa do to endometriosis?

Orilissa is a medication that helps manage the symptoms of endometriosis by reducing the levels of estrogen in the body. This reduction in estrogen can alleviate pain and other symptoms associated with endometriosis.

Orilissa and Lupron are not the same medication, although both are used to manage symptoms associated with endometriosis. Orilissa (elagolix) is an oral medication that works as a gonadotropin-releasing hormone (GnRH) antagonist, while Lupron (leuprolide acetate) is an injectable medication that acts as a GnRH agonist. They have different mechanisms of action and administration methods.

Orilissa, a medication used to manage pain associated with endometriosis, has several potential drawbacks. Common side effects include hot flashes, headaches, nausea, and mood changes. It may also lead to decreased bone mineral density with long-term use, which could increase the risk of osteoporosis. Additionally, Orilissa can cause liver enzyme elevations, so liver function should be monitored. It is not recommended for use in individuals with severe liver impairment or during pregnancy, as it may harm the fetus. As with any medication, it is important to discuss potential risks and benefits with a healthcare provider.

Orilissa is not like birth control. While both Orilissa and birth control pills can be used to manage symptoms related to menstrual cycles, they work differently. Orilissa is specifically used to manage moderate to severe pain associated with endometriosis by reducing estrogen levels, whereas birth control pills primarily prevent pregnancy and can also help regulate menstrual cycles and reduce menstrual pain.

Orilissa should not be taken by individuals who are pregnant, as it may harm the unborn baby. It is also contraindicated in those with severe liver impairment. Additionally, individuals with a history of osteoporosis or those who are at increased risk for bone loss should avoid using Orilissa, as it can decrease bone mineral density. It is important for patients to discuss their full medical history with their healthcare provider before starting Orilissa to ensure it is safe for them.