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This document outlines crucial safety warnings and contraindications for Humatin (paromomycin). It is important to understand these risks and precautions to ensure safe use of the medication. Always consult your healthcare provider with any concerns or questions.

• Risk of New Infection: Humatin (paromomycin) is not effective against all bacteria and germs, which means some may survive and potentially cause a new infection. If you develop a new fever, experience worsening symptoms, or do not improve after completing your treatment, contact your healthcare provider immediately.

• Risk of Kidney Injury with Intestinal Ulcers: Generally, Humatin (paromomycin) is not absorbed into the body as it passes through the intestines. However, if you have ulcers in your intestines, some medication may be absorbed, potentially leading to kidney injury. Inform your prescriber of any intestinal ulcer conditions before starting treatment.

• Contraindication - Intestinal Blockage: Humatin (paromomycin) should not be used by individuals with an intestinal blockage due to the risk of serious health complications. If you have this condition, consult your healthcare provider before using this medication.

These points ensure you are informed about the potential risks and necessary precautions associated with Humatin (paromomycin). Always follow your healthcare provider’s guidance for safe use.

Common side effects:

• Nausea
• Stomach cramps
• Diarrhea

Paromomycin, an aminoglycoside antibiotic, can interact with various medications, potentially altering its effectiveness or increasing the risk of adverse effects. It's essential to be aware of these interactions to ensure safe and effective treatment.

Hormonal Contraceptives: Paromomycin may reduce the effectiveness of oral contraceptives by altering intestinal flora, which can affect hormone absorption. While the risk of contraceptive failure is considered low, it's advisable to use additional or alternative contraceptive methods during paromomycin therapy.

Nephrotoxic Agents: Combining paromomycin with other drugs that can harm the kidneys, such as certain diuretics (e.g., Furosemide) or other aminoglycosides (e.g., gentamicin), may increase the risk of kidney damage. Close monitoring of kidney function is recommended when these medications are used together.

Neuromuscular Blocking Agents: Paromomycin can enhance the effects of neuromuscular blockers like metocurine, potentially leading to severe respiratory depression. This combination should be avoided when possible, and if used, requires careful monitoring of respiratory function.

Botulinum Toxins: The concurrent use of paromomycin with botulinum toxin products may result in increased neuromuscular weakness. Caution is advised, and patients should be monitored for signs of excessive muscle weakness.

Methotrexate: Paromomycin may decrease the absorption of oral methotrexate, potentially reducing its effectiveness. Monitoring methotrexate levels and therapeutic response is advisable when these drugs are used together.

Probiotics: Taking paromomycin with probiotics may reduce the effectiveness of the probiotics, as the antibiotic can kill the beneficial bacteria. To minimize this interaction, it's recommended to separate the administration of paromomycin and probiotics by at least two hours.

Live Typhoid Vaccine: Paromomycin can decrease the effectiveness of the live typhoid vaccine. It's recommended to complete antibiotic treatment before receiving this vaccine.

Always inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting paromomycin to avoid potential interactions and ensure safe use.