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Promethazine carries significant risks, particularly for young children. Please review these important safety details:

• Children Under 2 Years: This medication is not safe for children younger than 2 years due to the risk of severe, potentially life-threatening respiratory depression. Even standard doses have been associated with slow or shallow breathing in this age group.

• Dosage Recommendations: Always use the smallest effective dose of Promethazine to minimize risk. Avoid using it alongside other medications that may impact respiratory function.

• Emergency Response: If slow or shallow breathing occurs, seek immediate medical attention.

• Children with Liver Conditions: Promethazine is contraindicated for children with liver disorders, including those diagnosed with or suspected of having Reye's syndrome.

By following these guidelines, you can help ensure the safe use of Promethazine in vulnerable populations.

This medication may cause mild side effects such as drowsiness, dizziness, blurred vision, nausea, constipation, or dry mouth. These often improve over time, but if they persist or worsen, consult with your healthcare provider. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

In rare cases, more serious side effects can occur. Contact your healthcare provider immediately if you experience decreased coordination, difficulty urinating, tremors, mood changes (like nervousness, excitement, irritability, confusion, hallucinations), abnormal movements, slow heartbeat, or fainting. If you become very sleepy or have trouble waking up, discontinue use and seek medical advice promptly, as a dosage adjustment may be required.

Seek emergency medical attention if you encounter very serious side effects, such as slow or shallow breathing or seizures. Additionally, this medication can rarely lead to a severe condition known as neuroleptic malignant syndrome (NMS), with symptoms like fever, muscle stiffness, severe tiredness, confusion, sweating, irregular heartbeat, dark urine, or signs of kidney problems.

While a severe allergic reaction to this medication is uncommon, it necessitates immediate medical attention if you notice symptoms such as rash, itching or swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing. If you experience any other unexpected side effects, contact your healthcare provider.

Certain products can interact with this medication. These include skin-applied antihistamines like diphenhydramine (found in anti-itch creams, ointments, and sprays), as well as drugs like Metoclopramide and rolapitant. Additionally, using MAO inhibitors with this medication can lead to a serious, potentially life-threatening reaction. You should not take isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while using this drug. Most MAO inhibitors should also be avoided for two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue use.

The likelihood of severe side effects, such as difficulty breathing or extreme drowsiness, increases when this medication is combined with other substances that cause drowsiness or breathing issues. Inform your doctor if you are using opioids (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or other antihistamines (such as Cetirizine or diphenhydramine).

Always check your medication labels, including those for allergy or cold remedies, as they may contain ingredients that induce drowsiness. Consult your pharmacist to ensure safe use of these products.

Dextromethorphan is present in both prescription and over-the-counter medications. Review all your medication labels to avoid taking more than one dextromethorphan-containing product.

This medication might affect certain laboratory tests, such as urine pregnancy tests or skin allergy tests, potentially leading to inaccurate results. It's essential to inform laboratory staff and all your healthcare providers about your use of this medication.