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The following information outlines important safety considerations and warnings associated with the use of this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Proper Usage: Only use topical lidocaine as instructed by your healthcare provider. Do not exceed the recommended dose or frequency of application, as this can lead to an accumulation of the medication in your system. Avoid applying topical lidocaine to infected wounds or severely damaged skin without consulting your doctor, as these conditions may increase absorption. Excessive lidocaine levels can cause serious side effects, including seizures, respiratory difficulties, low blood pressure, reduced heart rate, and cardiac arrest. Seek immediate medical attention if you experience any of these symptoms.

• Methemoglobinemia Risk: Lidocaine 5% ointment and LiDORx (lidocaine) 3% gel may lead to methemoglobinemia, a condition where red blood cells are unable to deliver adequate oxygen to the body. The risk is heightened for individuals with low G6PD levels, a hereditary condition that causes red blood cells to rupture. Exercise caution when using topical lidocaine around oxidizing agents like chlorine and hydrogen peroxide, commonly found in household products such as cleaning supplies and hair dyes. Methemoglobinemia can manifest immediately or within hours of application, with early symptoms including headache, fatigue, and cyanosis (skin turning blue). Prompt medical intervention is crucial to prevent severe complications such as seizures, loss of consciousness, and arrhythmias (irregular heartbeats), particularly fast heartbeats, dizziness, or shortness of breath. Those with a history of methemoglobinemia, low G6PD, heart or lung issues, infants aged six months or younger, or exposure to oxidizing agents should be particularly cautious.

There are no listed contraindications for this medication.

This medication can cause a range of side effects, varying in severity. Common side effects include lightheadedness, dizziness, drowsiness, fatigue, ringing in the ears, blurred or double vision, and vomiting. Some individuals may also feel temperature changes, experience twitching or shaking, or have seizures. In rare cases, more severe symptoms such as coma, difficulty breathing, a slow heart rate, and low blood pressure may occur. These symptoms are generally mild, but if they persist or worsen, it is advisable to consult a healthcare provider.

Other reported side effects include feelings of nervousness, an overwhelming sense of joy, and confusion. While these are not typically dangerous, any concerning changes should be discussed with a healthcare professional.

There are also serious side effects that, although uncommon, require immediate medical attention. Blood problems like methemoglobinemia can manifest as seizures, loss of consciousness, rapid heart rate, difficulty breathing, dizziness, fatigue, and a bluish skin tone. Excessive amounts of lidocaine in the body may cause drowsiness, confusion, a slow heart rate, breathing difficulties, and challenges in controlling muscle movements. Severe allergic reactions, characterized by facial swelling, breathing difficulties, trouble speaking, throat constriction, red and itchy rash, lightheadedness, and clammy skin, also necessitate urgent care. Always remain vigilant for these severe symptoms and seek immediate help if they occur.