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Meperidine

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meperidine

Meperidine, also known by the brand name Demerol, is an opioid analgesic used to manage moderate to severe pain when other treatments are ineffective. It is particularly useful for short-term relief from sudden pain episodes and may also be administered before and during surgical procedures. This medication operates by binding to specific proteins in the brain, altering the way pain is perceived and reducing the sensation of pain. It is important to note that meperidine should not be used for chronic pain due to potential serious side effects, including withdrawal symptoms if discontinued abruptly. Meperidine is available in various forms, including pills, liquid, and injections, both as a generic and brand-name product. It is not recommended for use in newborns due to the risk of severe side effects. Always consult with a healthcare provider to ensure safe and effective use tailored to your needs.
Our Demerol coupons are free to use. You can print the coupon, email it to yourself, or receive the Demerol coupon via text message. To get your free discount, show the pharmacist your Demerol savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Demerol prices will update based on your prescription needs. Above our Demerol coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Demerol savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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1ML of 100MG/ML, Meperidine (1 Vial)

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CVS

$21.80

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$2.00

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$3.44

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$10.37

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Demerol dosage forms

The average cost for 1 Vial of Demerol (meperidine) at 1ML of 100MG/ML is $2 with a free coupon. This is 10.58% off the average retail price of $18.91
DosageQuantityPrice fromPer unit
1ML of 100MG/ML1 Vial$2$2
1ML of 25MG/ML1 Vial$2$2
1ML of 50MG/ML1 Vial$2$2

Demerol Warnings

Meperidine, also known as Demerol, requires careful use due to its potential risks and side effects. Below are important safety and warning details to consider:

  • Risk of Abuse and Addiction: Meperidine has a high potential for abuse and addiction, which can result in overdose and death. Use the smallest effective dose for the shortest duration possible. Discuss with your healthcare provider about having naloxone available for opioid overdose emergencies.

  • Respiratory Risks: This medication can cause dangerously slow breathing, especially at the start of treatment, after a dose increase, or if taken incorrectly. Combining it with alcohol or other sedatives increases this risk. Immediate medical attention is necessary if you experience slow or shallow breathing, unusual lightheadedness, or severe drowsiness.

  • Drug Interactions: Meperidine can interact with various substances, affecting its efficacy and safety. Avoid combining it with alcohol, benzodiazepines, other opioids, or medications that elevate serotonin levels, as these can lead to severe side effects, including respiratory depression and serotonin syndrome.

  • Pregnancy and Newborn Risks: Women of childbearing age should consult their doctor about the risks of using meperidine during pregnancy. Prolonged use can lead to neonatal opioid withdrawal syndrome in newborns, which may be life-threatening. Use only when absolutely necessary during pregnancy and at the lowest effective dose.

  • Overdose Symptoms: Signs of an overdose include unresponsiveness, extremely slow breathing, severe drowsiness, slow heartbeat, and cold, clammy skin. If an overdose is suspected, seek emergency medical help immediately.

  • Physical Dependence and Withdrawal: Long-term use can lead to physical dependence. Do not abruptly stop taking this medication without consulting your healthcare provider to avoid withdrawal symptoms such as anxiety, restlessness, and body aches.

  • Special Populations: Individuals with a history of seizures, heart rhythm problems, or gastrointestinal blockages should use meperidine with caution and only under medical supervision.

  • Contraindications: Do not use meperidine if you have severe breathing problems, acute asthma, or if you are taking or have recently taken monoamine oxidase inhibitors (MAOIs).

It is crucial to store this medication securely to prevent misuse or theft and to ensure that only those for whom it is prescribed have access to it. Always consult your healthcare provider with any questions or concerns about using meperidine safely.

Demerol Side Effects

When taking this medication, you may experience some common side effects such as lightheadedness, dizziness, drowsiness, nausea, vomiting, sweating, and constipation. These effects are usually mild, but if they persist or worsen, consult your healthcare provider. To alleviate constipation, consider increasing your dietary fiber, staying hydrated, and staying active. Dizziness and lightheadedness can be minimized by rising slowly from sitting or lying positions.

There are other side effects that can occur, including weakness, headache, tremors, confusion, dry mouth, and low blood pressure. If any of these side effects become severe, seek medical advice. In rare instances, allergic reactions may occur, characterized by trouble breathing, hives, or swelling of the face, lips, tongue, or throat. These reactions require immediate medical attention.

Serious side effects, though uncommon, necessitate urgent care. These include dangerously slow breathing, extremely low blood pressure, and symptoms of overdose like extreme sleepiness, slow heartbeat, or cold and clammy skin. Serotonin syndrome is another severe condition that may arise, marked by fast heart rate, muscle twitching, or seizures. If you experience any symptoms of serotonin syndrome or serious allergic reactions, seek immediate medical help. Recognizing these signs early can prevent complications and ensure your safety.

Demerol Interactions

Certain medications can interact with this drug, potentially causing harmful effects. It's important to avoid using mixed opioid agonist-antagonists like Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone and samidorphan, while taking this medication. Additionally, using MAO inhibitors—such as isocarboxazid, Linezolid, and Selegiline—with this medication can lead to a serious and possibly fatal reaction. Therefore, do not take MAO inhibitors during treatment and generally avoid them for two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue use.

Using this medication with other substances that cause drowsiness or breathing issues can increase the risk of severe side effects like slow or shallow breathing and extreme drowsiness. Be sure to tell your doctor if you are using other opioid pain or cough relievers, alcohol, marijuana, sleep or anxiety medications, muscle relaxants, or antihistamines. Check the labels on all your medications, including those for allergies or colds, as they may contain ingredients that cause drowsiness. Consult your pharmacist for safe usage advice.

The risk of serotonin syndrome, a potentially serious condition, increases if you take other drugs that raise serotonin levels, such as certain antidepressants or street drugs like MDMA. This risk is higher when starting or increasing the dosage of these drugs.

Some medications can affect how your body processes this drug, altering its effectiveness. These include azole antifungals, macrolide antibiotics, Mifepristone, rifamycins, Ritonavir, and certain seizure medications.

Lastly, this drug may interfere with certain lab tests, such as amylase or lipase tests, possibly leading to inaccurate results. Inform laboratory personnel and all your healthcare providers that you are taking this medication.

Demerol FAQs
What is the use of Demerol?

Demerol is used to help relieve moderate to severe pain. It is an opioid analgesic that works by changing how the brain and nervous system respond to pain.

Demerol, also known as meperidine, is less commonly prescribed due to several concerns. It has a higher risk of causing seizures, especially in patients with renal impairment, due to the accumulation of its metabolite, normeperidine. Additionally, it has a short duration of action and can interact with other medications, increasing the risk of serotonin syndrome. Safer and more effective alternatives are available, which has led to a decline in its use.

Demerol and morphine are not the same. They are both opioid pain medications, but they have different chemical structures and are used in different clinical situations. Demerol, also known as meperidine, is typically used for moderate to severe pain, while morphine is often used for more severe pain. They also have different side effect profiles and dosing considerations.

Demerol and oxycodone are both opioid medications used to manage pain, but they have some differences. Demerol, also known as meperidine, is typically used for short-term pain relief and is less commonly prescribed due to its potential for causing central nervous system toxicity with prolonged use. Oxycodone, on the other hand, is often used for both acute and chronic pain management and is available in various formulations, including immediate-release and extended-release. Additionally, oxycodone is generally considered to be more potent than Demerol. Both medications carry a risk of addiction and should be used under careful medical supervision.

Demerol (meperidine) has not been completely discontinued, but its use has become more restricted. It is still available, but due to concerns about its safety and potential for abuse, many healthcare providers have shifted to using other pain management options. It is important for patients to consult with their healthcare provider to discuss appropriate pain management strategies.