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Buprenorphine carries a risk of misuse and dependency, potentially leading to overdose or fatality. It can also cause dangerous, possibly life-threatening respiratory issues. To minimize these risks, it is crucial that your healthcare provider prescribes the lowest effective dose for the shortest duration necessary.

• Consider having naloxone available to counteract an opioid overdose; consult your healthcare provider or pharmacist for guidance. Educate your family or household members on recognizing opioid overdose signs and the appropriate response.
• The likelihood of severe breathing difficulties is elevated when initiating treatment, after increasing the dosage, or if an incorrect dose/strength is used.
• Combining buprenorphine with alcohol or other substances that induce drowsiness or respiratory depression can result in serious, potentially fatal side effects. Ensure you understand how to use buprenorphine correctly and are aware of substances to avoid.
• Immediate medical assistance is required if you experience symptoms such as slow or shallow breathing, unusual lightheadedness, severe drowsiness or dizziness, or difficulty waking up.

Women of childbearing age should discuss the risks and benefits with their healthcare provider prior to using this medication. Inform your doctor if you are pregnant or planning to become pregnant. This medication should only be used during pregnancy when absolutely necessary, as it may slightly increase the risk of birth defects in the first two months of pregnancy. Prolonged or high-dose use near the expected delivery date may harm the unborn child. To reduce risks, use the smallest effective dose for the shortest possible time. Newborns of mothers who have used this drug long-term may experience severe, potentially fatal, withdrawal symptoms. Contact a doctor immediately if your newborn shows symptoms such as persistent crying, slow or shallow breathing, irritability, tremors, vomiting, diarrhea, feeding difficulties, or trouble gaining weight.

When taking this medication, you may experience mild side effects such as nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, or sweating. These typically ease as your body adjusts. Some may notice redness, itching, or irritation at the injection site, which is generally temporary. To manage constipation, consider a diet rich in fiber, adequate hydration, and regular exercise. A suitable laxative might also be recommended. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

While serious side effects are uncommon, be alert to symptoms like interrupted breathing during sleep, mental or mood changes, difficulty urinating, or signs of poor adrenal function, such as appetite loss, unusual tiredness, or weight loss. Seek immediate medical attention for very serious side effects, including fainting, seizures, slow or shallow breathing, severe drowsiness, difficulty waking, irregular heartbeat, or severe dizziness.

Although rare, buprenorphine can cause severe liver damage. If you experience persistent nausea or vomiting, appetite loss, abdominal pain, yellowing of the eyes or skin, or dark urine, seek urgent care. Allergic reactions are also rare, but require immediate attention if symptoms like rash, itching, swelling, severe dizziness, or breathing difficulties occur. If you notice any other unusual effects, consult with your healthcare provider.