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When using nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, it's important to be aware of potential risks and necessary precautions. Below is essential safety and warning information to consider:

• Cardiovascular Risks: Ibuprofen may increase the risk of heart attack or stroke, potentially occurring at any point during use, and is more likely with long-term use. The risk is higher for older adults and those with pre-existing heart conditions or risk factors like smoking, family history, high blood pressure, or diabetes. Do not use ibuprofen immediately before or after coronary artery bypass graft (CABG) surgery.

• Gastrointestinal Risks: Serious bleeding in the stomach or intestines is a rare but possible side effect that can happen without warning. This risk is also higher for older individuals.

• Emergency Symptoms: Discontinue use and seek immediate medical attention if you experience severe stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden vision changes.

• Consultation: Discuss with your healthcare provider to understand the benefits and risks associated with ibuprofen use.

These precautions are crucial for safe and informed use of ibuprofen. Always consult with a healthcare professional for personalized advice and guidance.

Certain medications can interact with this drug, potentially altering its effects or increasing side effects. These include: Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics, commonly known as "water pills," such as Furosemide.

Additionally, this medication may heighten the risk of bleeding when used with other drugs that also increase bleeding risk. Such drugs include anti-platelet medications like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, and Warfarin.

Be attentive to both prescription and nonprescription drug labels, as many contain pain relievers or fever reducers like Aspirin or NSAIDs such as Celecoxib, Ketorolac, or Naproxen. These are similar to ibuprofen and may raise the likelihood of adverse effects if combined. However, if your healthcare provider has advised you to take low-dose aspirin (typically 81-162 milligrams per day) to reduce the risk of heart attack or stroke, continue doing so unless instructed otherwise. It's important to note that daily ibuprofen use might reduce aspirin's effectiveness in preventing heart attacks or strokes. Discuss with your doctor about alternative medications, such as Acetaminophen, for managing pain or fever. If ibuprofen is necessary, consult your doctor about timing your doses correctly when also taking immediate-release aspirin (not enteric-coated). Specifically, take ibuprofen at least 8 hours before or 2 hours after your aspirin dose. Do not change your aspirin dosage or how you take any of your medications without consulting your doctor.