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Hydrocodone, a medication used for pain management, carries significant risks and requires careful use. Below are critical safety warnings and precautions to consider:

• Risk of Abuse and Addiction: Hydrocodone is a controlled substance with a potential for abuse and addiction. Misuse can result in life-threatening conditions, including overdose and death. Individuals with a personal or family history of substance use disorder or mental health conditions should exercise caution.

• Respiratory Depression: This medication can cause dangerously slow breathing, particularly when starting treatment or increasing the dose. Caution is advised for people with breathing issues such as COPD or asthma, older adults, and those taking other medications or substances that depress the respiratory system, including alcohol.

• Overdose Risk: Follow the prescription exactly to avoid overdose. Symptoms of an overdose include slow or shallow breathing, extreme drowsiness, cold or clammy skin, and unresponsiveness. Keep hydrocodone out of reach of children and pets. In case of an overdose, use naloxone if available and seek emergency medical help immediately.

• Interactions with Other Substances: Combining hydrocodone with alcohol or medications like benzodiazepines, muscle relaxants, or sleep aids can enhance drowsiness and respiratory depression. Always inform your healthcare provider about all medications and supplements you are taking to prevent harmful interactions.

• Pregnancy and Newborn Risks: If used during pregnancy, especially long-term, hydrocodone can lead to dependence in the unborn baby, resulting in withdrawal symptoms after birth. Pregnant individuals should discuss risks and benefits with their healthcare provider.

• Dependence and Withdrawal: Long-term use can lead to physical dependence. Abruptly stopping the medication may cause withdrawal symptoms such as anxiety, irritability, body aches, and chills. Consult with your healthcare provider before making any changes to your dosage.

• Low Blood Pressure and Adrenal Insufficiency: Hydrocodone can cause low blood pressure and, in some cases, low adrenal hormone levels, especially with long-term use. Symptoms include dizziness, muscle weakness, and nausea. Monitor for these symptoms and report them to your healthcare provider.

• QT Prolongation and Heart Rhythm Issues: Although rare, this medication can affect heart rhythm, leading to conditions like QT prolongation. Individuals with a history of heart issues should be closely monitored.

• Seizure Risk: Those with a history of seizures may be at increased risk. Seek immediate medical attention if seizures occur while on this medication.

• Storage and Safety: Store hydrocodone securely to prevent theft or misuse. Do not crush, chew, or dissolve the medication, as this can lead to a potentially fatal overdose.

For any concerns or more information on how to use this medication safely, consult your healthcare provider.

Common side effects:

• nausea
• vomiting
• constipation
• dizziness
• lightheadedness
• drowsiness
• headache
• sleepiness

Less common but important to monitor:

• interrupted breathing during sleep (sleep apnea)
• mental and mood changes such as agitation, confusion, or hallucinations
• abdominal pain
• difficulty urinating
• signs of adrenal gland issues like unusual tiredness or weight loss

Serious side effects:

• fainting
• fast or irregular heartbeat
• seizures
• severe drowsiness
• allergic reaction symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Nalmefene
• Naltrexone
• Safinamide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Butorphanol
• Nalbuphine
• Pentazocine
• Azole antifungals (e.g., Ketoconazole)
• Macrolide antibiotics (e.g., Erythromycin)
• Rifamycins (e.g., Rifampin)
• Codeine
• Oxycodone
• Alcohol
• Marijuana
• Alprazolam
• Lorazepam
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine