Clopidogrel

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clopidogrel

Clopidogrel, also known by the brand name Plavix, is a medication prescribed to prevent heart attacks and strokes, particularly in individuals with existing heart conditions, recent heart attacks, strokes, or circulation issues like peripheral vascular disease. It is also used in combination with aspirin to manage new or worsening chest pain, such as a new heart attack or unstable angina, and to ensure blood vessels remain open after certain procedures like the placement of a cardiac stent. As an antiplatelet drug, Clopidogrel functions by inhibiting platelets from clumping together, thereby preventing the formation of harmful clots that could obstruct blood flow in the heart or brain. This action significantly reduces the risk of heart attacks or strokes. The medication is taken orally once daily and is available both as a brand-name drug and in generic form. Since it acts as a blood thinner, side effects like bleeding and bruising may occur, especially if taken with certain other medications such as antidepressants, anticoagulants, or NSAIDs. Always consult your healthcare provider before starting Clopidogrel to ensure it is safe and effective for your specific health needs.
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75MG, Clopidogrel (30 Tablets)

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CVS

$19.23

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$4.44

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$5.33

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$10.29

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$18.19

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Plavix dosage forms

The average cost for 30 Tablets of Plavix (clopidogrel) at 75MG is $4.44 with a free coupon. This is 11.68% off the average retail price of $38.01
DosageQuantityPrice fromPer unit
75MG30 Tablets$4.44$0.15

Plavix Warnings

This information outlines crucial safety and warning details for the use of this medication. Please read carefully and consult your healthcare provider if you have any questions or concerns.

  • Reduced Effectiveness in Certain Individuals: Some individuals may not experience the full benefits of clopidogrel (Plavix) due to genetic differences affecting drug metabolism. Avoid starting new medications, vitamins, or supplements without consulting your healthcare provider, as these may impact the effectiveness of clopidogrel (Plavix). Notably, medications like omeprazole (Prilosec) and esomeprazole (Nexium) may interfere with its action.

  • Increased Bleeding Risk: Clopidogrel (Plavix) can heighten your bleeding risk and may prolong bleeding time. You might experience easy bruising or increased bleeding from cuts or nosebleeds. This risk is augmented if you are taking other blood-thinning medications. Contact your healthcare provider immediately if you notice unusual bleeding, blood in your stool or urine, or if you experience dizziness. Seek emergency care if you suffer from a fall, head injury, or any severe physical injury that could result in internal bleeding. Notify your provider if you have dark, tarry stools or persistent bleeding.

  • Risk of Heart Attack or Stroke: Do not discontinue clopidogrel (Plavix) without your provider’s approval, as abrupt cessation can lead to a heart attack or stroke. If you need to stop taking the medication, consult your provider for a safe discontinuation plan, especially if you have recently had a heart attack or stent placement.

  • Thrombotic Thrombocytopenic Purpura (TTP): This medication can cause a rare, potentially fatal condition known as thrombotic thrombocytopenic purpura (TTP), characterized by blood clots in small vessels. Symptoms can appear within two weeks of starting clopidogrel (Plavix). Seek immediate medical attention if you experience fever, unusual bleeding, easy bruising, weakness, dizziness, fatigue, or breathing difficulties.

  • Allergic Reactions: Allergic reactions, including severe ones like anaphylaxis, are possible with clopidogrel (Plavix). If you have allergies to prasugrel (Effient) or ticagrelor (Brilinta), you may also be allergic to clopidogrel (Plavix). Discontinue use and contact your doctor if you develop a rash or hives. Seek immediate medical attention if you experience swelling of the face, throat, or tongue.

  • Contraindications: Clopidogrel (Plavix) should not be used in individuals with active bleeding. Always consult your healthcare provider to verify if this medication is safe for you.

Plavix Side Effects

When taking this medication, some individuals might experience common side effects, which are generally mild. These include minor bleeding, noted in about 5% of users, and major bleeding, occurring in approximately 4%. If these symptoms persist or worsen, it is advisable to consult your healthcare provider for guidance.

Other side effects reported by users include bruising, itchiness, and nosebleeds. Some individuals may also experience stomach and intestinal ulcers, headaches, changes in taste, or confusion. These effects can vary in intensity, and if they become severe, seeking medical advice is recommended.

It is important to be aware of serious side effects, even though they are rare. Severe bleeding may manifest as feeling faint, lightheaded, dizziness, vomiting blood, having bloody or dark-colored stools, or experiencing severe stomach pain. Additionally, a condition known as thrombotic thrombocytopenic purpura, a blood clotting problem, could occur, presenting symptoms such as headache, confusion, dizziness, fever, skin bleeding, bruising, tiredness, stomach pain, blood in the urine, or reduced urine output. Immediate medical attention is crucial if any of these symptoms arise.

Plavix Interactions

A product that may interact with this drug is: tipranavir. If you are currently taking aspirin, consult your doctor promptly and ask whether to continue or stop taking it with this medication for your specific condition (aspirin and clopidogrel may be used in combination after a coronary stent procedure, or for some heart conditions). If you are not currently taking aspirin, consult your doctor before starting it for any medical condition. Other medications can affect the removal of clopidogrel from your body, which may affect how clopidogrel works. Examples include certain acid reducers (proton pump inhibitors/PPIs such as omeprazole, esomeprazole), cimetidine, etravirine, felbamate, fluconazole, fluoxetine, fluvoxamine, ketoconazole, rifampin, voriconazole, among others. Clopidogrel can slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include repaglinide, tovorafenib, among others. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin). These drugs may increase the risk of bleeding/antiplatelet effect when used with clopidogrel. Ask your pharmacist about using these products safely.
Plavix FAQs
Is Plavix a blood thinner or anticoagulant?

Plavix is considered an antiplatelet medication, which is a type of blood thinner. It works by preventing platelets in the blood from clumping together to form clots.

The duration for which a patient should be on Plavix (clopidogrel) depends on the specific medical condition being treated and the individual's response to the medication. Typically, for patients who have had a stent placed in their coronary arteries, Plavix is often prescribed for at least 6 to 12 months. For those with a history of stroke or peripheral artery disease, it may be prescribed for a longer duration. It is essential for patients to follow their healthcare provider's recommendations and not to stop taking Plavix without consulting their doctor, as doing so could increase the risk of a cardiovascular event.

Plavix, also known as clopidogrel, can have several potential downsides or side effects. Common side effects include bleeding, bruising, and gastrointestinal issues such as stomach pain or indigestion. There is also a risk of more serious bleeding events, such as gastrointestinal bleeding or intracranial hemorrhage. Some individuals may experience allergic reactions or skin rashes. Additionally, Plavix may interact with other medications, which can affect its efficacy or increase the risk of side effects. It is important for individuals to discuss their medical history and current medications with their healthcare provider to assess the risks and benefits of taking Plavix.

The decision to stop Plavix (clopidogrel) after 6 months should be made by a healthcare provider, as it depends on the individual's medical condition and the reason for which Plavix was prescribed. It is important to follow the guidance of a healthcare professional, as stopping Plavix without medical advice can increase the risk of complications, especially if it was prescribed for conditions like coronary artery disease or after a stent placement.

Plavix (clopidogrel) is generally considered safe for long-term use in patients who require it for preventing blood clots, such as those with certain heart or blood vessel conditions. However, the safety and duration of use should be regularly evaluated by a healthcare provider, as long-term use can increase the risk of bleeding. It is important for patients to have regular follow-ups with their healthcare provider to monitor for any potential side effects or complications.