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This document provides essential safety and warning information for those taking dabigatran (Pradaxa). It is crucial to understand the potential risks and necessary precautions associated with this medication. Please review the following points carefully and consult your healthcare provider with any questions or concerns.

• Do Not Discontinue Without Guidance: It is important not to stop taking dabigatran unless directed by your healthcare provider. Premature discontinuation can significantly increase the risk of forming serious blood clots, such as those leading to a stroke or clots in the legs or lungs. Your doctor may prescribe an alternative blood-thinning or antiplatelet medication to help manage this risk.

• Emergency Symptoms: Seek immediate medical attention if you experience symptoms such as weakness on one side of the body, difficulty speaking, sudden changes in vision, confusion, chest pain, trouble breathing, or pain, warmth, and swelling in the legs.

• Risk of Paralysis from Spinal Procedures: Those undergoing certain spinal procedures while on dabigatran may have an increased risk of bleeding near the spinal cord, potentially resulting in long-term or permanent paralysis. Discuss the benefits and risks with your doctor if you plan to have a spinal procedure, especially if you have a deformed spine, a history of spinal surgery, or are using other medications that increase bleeding risk.

• Bleeding Risk: Dabigatran can elevate your risk of bleeding, particularly if you are also taking medications that cause bleeding. In life-threatening bleeding situations, a reversal agent known as Praxbind (idarucizumab) may be administered. Notify your healthcare provider of any falls, head injuries, or other injuries that may indicate internal bleeding. Seek immediate help if you notice dark or tarry stools or bleeding that is difficult to control.

• Medication Interactions: Certain medications can alter the effectiveness of dabigatran, either increasing the risk of bleeding or reducing its efficacy. Inform your healthcare team about any other medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements you are currently taking or have recently stopped.

• Contraindications: Dabigatran should not be used in individuals with mechanical heart valves or antiphospholipid syndrome due to increased risks of stroke, heart attack, blood clots, and life-threatening bleeding. Alternative treatments should be discussed with a healthcare provider.

• Active Bleeding: Dabigatran is contraindicated in individuals with active bleeding.

It is vital to follow your healthcare provider's instructions and to communicate any concerns or symptoms promptly to ensure safe and effective use of dabigatran.

When taking this medication, some individuals may experience mild side effects such as an upset stomach, nausea, stomach pain, easy bruising, or minor bleeding like nosebleeds or bleeding from small cuts. These symptoms are usually not severe, but if they persist or worsen, it is advisable to consult your healthcare provider.

However, there are more serious side effects to be aware of. This medication can cause significant bleeding issues, particularly if it affects blood clotting proteins. Signs of serious bleeding include frequent or unstoppable nosebleeds, unusual tiredness or weakness, unexplained pain or swelling, prolonged bleeding from cuts or gums, heavy or prolonged menstrual bleeding, pink or dark urine, coughing up blood, vomit that resembles coffee grounds, severe headaches, dizziness, fainting, or bloody or black stools. If you encounter these symptoms, seek medical attention immediately.

In very rare cases, some individuals might experience severe allergic reactions. Symptoms of a serious allergic reaction include a rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. Immediate medical help is essential if these occur. Additionally, serious side effects such as severe bleeding after spinal procedures or bleeding around the spinal cord, causing pain, tingling, burning sensations, numbness, weakness, or difficulty in using the bathroom require urgent medical care.

Other reported side effects include stomach ulcers, low blood cell counts, and hair loss. If you notice any side effects that are not listed or if you have concerns about your symptoms, it is important to contact your healthcare provider for guidance.

When taking Dabigatran (Pradaxa), it's important to be aware of potential interactions with other medications. Certain drugs, such as Mifepristone, can interact with Dabigatran and increase the risk of bleeding, especially when combined with antiplatelet medications like Clopidogrel, NSAIDs such as Ibuprofen or Naproxen, and blood thinners like Warfarin or apixaban. [Aspirin](https://savehealth.com/aspirin) may also heighten bleeding risks; however, continue taking low-dose aspirin for heart attack or stroke prevention if your doctor has advised it.

Additionally, certain medications can affect how Dabigatran is processed in your body, potentially altering its effectiveness. These include cobicistat, Cyclosporine, dronedarone, Ketoconazole, Rifampin, St. John's wort, and seizure medications like Carbamazepine and Phenytoin.

Some drugs, like Defibrotide and Itraconazole, are not recommended for use with Dabigatran. Others, such as abciximab, Amiodarone, aspirin, and many more, may require careful monitoring and dose adjustments if used together with Dabigatran, as they might elevate the risk of adverse effects. Always consult your healthcare provider to manage these interactions safely.