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The following safety information provides essential guidance regarding the use of Simbrinza (brinzolamide / brimonidine) eye drops. Please read carefully and discuss any questions with your healthcare provider.

• Usage Instructions: Simbrinza should only be applied to the surface of the eye. Do not ingest or inject this medication.

• Allergic Reactions: If you are allergic to sulfa medications such as Bactrim (sulfamethoxazole / trimethoprim), consult your healthcare provider before using Simbrinza, as it contains brinzolamide, a sulfa medication, which may cause severe allergic reactions.

• Corneal Swelling Risk: Individuals with a thin cornea or a reduced number of corneal cells should seek advice from an eye specialist before using Simbrinza, as it may increase the risk of corneal edema.

• Blood Flow Concerns: Simbrinza contains brimonidine, which could potentially exacerbate conditions related to poor blood flow, such as depression, Raynaud's phenomenon, orthostatic hypotension, and serious heart problems. Disclose your full medical history to your prescriber to ensure appropriate monitoring.

• Infection Prevention: To avoid contamination and subsequent eye infections, wash your hands before application and avoid contact between the dropper tip and any surfaces, including your eye.

• Contact Lens Instructions: Remove soft contact lenses prior to using Simbrinza due to the preservative benzalkonium chloride, which can damage lenses. Wait at least 15 minutes after applying the drops before reinserting lenses.

Contraindications:

• Do not use Simbrinza if you are under 2 years of age or have known allergies to brinzolamide or brimonidine. Always consult your healthcare provider if these conditions apply to you.

When using this medication, some people may experience mild side effects that are generally not a cause for concern. These include blurry vision, eye discomfort such as itching or irritation, a dry sensation in the eyes or mouth, changes in taste like a bitter or sour flavor, dizziness, drowsiness, tiredness, and headaches. Although these effects are usually temporary, it is advisable to consult a healthcare provider if they persist or worsen.

There are also other side effects that, while not common, have been reported. These include a burning or stinging sensation in the eyes, eye redness, and tiredness. If these side effects occur, especially if they become severe, seeking medical advice is recommended to ensure that they are managed appropriately.

In rare cases, serious side effects can occur and necessitate immediate medical attention. These include fast or irregular heartbeats, eye or eyelid pain, burning, swelling, extreme sensitivity to light, vision changes, fainting, and difficulty breathing. A very serious allergic reaction is uncommon but can manifest as a rash, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. If any symptoms of a serious allergic reaction appear, seek emergency medical assistance promptly.