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This medication, Sprix nasal spray (ketorolac), comes with important safety warnings to ensure safe usage. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Duration of Use: Do not use any ketorolac products, including this nasal spray, for more than 5 days total. It is not intended for minor or long-term painful conditions.

• Bleeding Risks: Ketorolac can significantly increase the risk of serious bleeding, including stomach or intestinal bleeding, which can occur without warning. This risk is heightened in older adults, those with a history of stomach bleeding, or those with liver problems. Avoid use if you have bleeding or clotting disorders. Alcohol and smoking can further elevate this risk.

• Heart and Stroke Risks: This medication may increase the risk of blood clots, heart attacks, and strokes, especially with prolonged use or in individuals with pre-existing heart conditions. Do not use this medication before or after heart surgery. Seek immediate medical attention if you experience chest pain, shortness of breath, or difficulty speaking.

• Kidney Concerns: Ketorolac can lead to kidney damage, particularly in older adults or those with conditions like diabetes. Monitor kidney function before and during treatment, and contact your healthcare provider if you notice changes in urination, fatigue, or muscle cramps.

• Interaction with Other NSAIDs: Avoid taking other NSAIDs alongside ketorolac, as this can increase the risk of severe side effects. Review all medications, including over-the-counter drugs, for potential NSAID content.

• Blood Pressure and Heart Failure: Ketorolac can cause fluid retention, leading to increased blood pressure or heart failure. Inform your healthcare provider of any history of heart issues or if you are on blood pressure medications.

• Liver Damage: Although rare, ketorolac can cause liver issues. Seek medical help if you experience symptoms like jaundice, stomach pain, or dark urine.

• Severe Allergic Reactions: Allergic reactions, including anaphylaxis, are possible. If you have known allergies to aspirin or NSAIDs, inform your healthcare provider prior to use. Seek immediate medical attention for symptoms like hives, facial swelling, or difficulty breathing.

Contraindications:

• Do not use if you have a history of stomach ulcers, asthma, or allergic reactions to NSAIDs.
• Avoid use before surgery, during labor and delivery, or after coronary artery bypass graft surgery.
• Refrain from using if you are at high risk for bleeding or taking other NSAIDs, probenecid, or pentoxifylline.

In case of an overdose, or if you experience any severe side effects, seek emergency medical assistance immediately. Always consult with your healthcare provider to weigh the benefits and risks of taking this medication.

When using this medication, some common side effects you might experience include mild nasal discomfort, nose pain, and excessive tearing. These symptoms are typically temporary and should not cause concern. However, if they persist or worsen, consider consulting your healthcare provider.

Occasionally, other side effects such as throat irritation, urinating less, rash, or a runny nose may occur. While these are not as common, it's important to monitor their severity and seek medical advice if needed.

In rare cases, serious side effects can occur and require immediate medical attention. These include symptoms of stomach bleeding like feeling faint, vomiting blood, having bloody or dark stools, or experiencing severe stomach pain. Signs of a heart attack or stroke, such as chest pain, trouble breathing, or sudden weakness should also prompt urgent care. Additionally, this medication may affect your heart and blood pressure, causing symptoms like difficulty breathing, swelling, fast heartbeat, or high blood pressure—which presents as headaches and changes in vision.

Liver and kidney issues are also rare but serious. Look out for yellowing of the skin or eyes, dark urine, confusion, or decreased urination. Allergic reactions, although uncommon, are severe if they involve hives, swelling of the lips or tongue, or difficulty breathing. Finally, serious skin reactions such as reddening, blisters, or rash warrant immediate medical attention. Always remain vigilant for these signs to ensure your safety while using the medication.

When using ketorolac, be aware of potential interactions with other medications. It is important to inform your doctor and pharmacist about all medications and supplements you are taking, including over-the-counter and herbal products.

Some drugs that should not be combined with ketorolac include other non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, aspirin, and naproxen. This can increase the risk of side effects. Additionally, avoid combining ketorolac with high doses of aspirin or other forms of ketorolac itself. If you have been prescribed low-dose aspirin for heart protection, continue taking it unless advised otherwise by your doctor.

Ketorolac may increase bleeding risk if used alongside anti-platelet medications like clopidogrel, or blood thinners such as warfarin and enoxaparin. It can also interact with corticosteroids like prednisone and certain diuretics like furosemide, affecting the drug's efficacy or leading to adverse effects.

Furthermore, certain medications can impact how ketorolac is metabolized in your body. Drugs such as leflunomide, probenecid, and teriflunomide may alter its removal, potentially affecting how ketorolac works.

It's essential to review all your medications with your healthcare provider to manage these interactions effectively.