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Sunitinib can lead to various side effects. Commonly, patients might experience an upset stomach, nausea, vomiting, diarrhea, or changes in taste and appetite. Some individuals may notice dry or thickened skin, watering eyes, swelling around the eyes, numbness or tingling in the limbs, or general tiredness. Although these effects are typically mild, it's important to monitor them and consult a healthcare professional if they persist or worsen. Hair loss and changes in hair or skin color may occur but are generally not harmful.

More serious side effects require immediate medical attention. These include severe headaches, rashes or blisters on the hands or feet, sores in the mouth, easy bruising or bleeding, and signs of low blood sugar such as shakiness and a rapid heartbeat. Patients should also be aware of symptoms like black or bloody stools, vomit resembling coffee grounds, coughing up blood, slow wound healing, and pain or swelling in the arms or legs, which could indicate a serious issue.

Sunitinib can cause an increase in blood pressure, so regular monitoring is recommended. In rare cases, it may lead to severe reactions such as trouble breathing, chest pain, severe dizziness, or irregular heartbeat, which require urgent medical care. Additionally, this medication may reduce the body's ability to fight infections, increasing the risk of serious infections. Symptoms of a serious allergic reaction, such as swelling of the face or throat, should also be addressed immediately.

In very rare instances, Sunitinib can cause severe skin reactions or tumor lysis syndrome, which can be life-threatening. Symptoms like painful urination or a change in urine color and muscle weakness should prompt immediate consultation with a healthcare provider. As with any medication, if you experience side effects not listed here, reach out to a healthcare professional for advice.

Sunitinib can interact with several medications, affecting its effectiveness and safety. It is important to inform your healthcare provider about all the medications you are taking. Some drugs that may interact with sunitinib include:

1. Bevacizumab and blood thinners like warfarin and heparins can increase the risk of bleeding.
2. Certain drugs can cause heart rhythm changes (QT prolongation), such as amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and some antibiotics like erythromycin.
3. Medications that influence the elimination of sunitinib from the body may alter its effects. These include azole antifungals (e.g., ketoconazole, itraconazole), cimetidine, some macrolide antibiotics (e.g., erythromycin), ritonavir, St. John's wort, and certain seizure medications (e.g., phenytoin, phenobarbital).

Consult your doctor or pharmacist for guidance on managing these interactions.