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The safety information for Spiriva (tiotropium) outlines crucial warnings and precautions you should be aware of when using this medication. It is essential to understand these details to ensure safe usage and to maintain open communication with your healthcare provider.

• Not a Rescue Inhaler: Spiriva (tiotropium) is designed for long-term management of symptoms and is not effective for immediate relief of sudden breathing difficulties. Always carry a rescue inhaler for emergencies.

• Allergic Reactions: Rare but severe allergic reactions can occur with Spiriva (tiotropium). Seek immediate medical attention if you experience difficulty breathing, swelling of the tongue, lips, or face, or severe itching and rash. Those with a history of allergic reactions to atropine, tiotropium, or ipratropium are at increased risk.

• Paradoxical Bronchospasm: Spiriva (tiotropium) can cause sudden airway tightening after inhalation. If this occurs, use your rescue inhaler and contact your healthcare provider promptly, as you may need to switch medications.

• Worsening Glaucoma: Individuals with narrow-angle glaucoma should use Spiriva (tiotropium) cautiously. Report any new eye pain, blurred vision, or visual changes, such as halos or color distortions, to your provider immediately.

• Urination Problems: Spiriva (tiotropium) can exacerbate urinary issues in those with prostate problems or urinary obstruction. Notify your provider if you experience difficulty or pain during urination.

• Increased Side Effects with Kidney Problems: People with kidney issues may experience more pronounced side effects due to drug accumulation, such as dry mouth, blurred vision, rapid heart rate, or constipation. Inform your healthcare provider if these symptoms arise.

• Contraindications: Do not use Spiriva (tiotropium) if you have an allergy to tiotropium or ipratropium, as it may lead to serious health risks.

Always consult your healthcare provider if you have any concerns or if any of the above conditions apply to you.

Common side effects:

• dry mouth
• upper respiratory tract infections
• sinus inflammation
• sore throat
• urinary tract infections
• chest pain
• cough
• runny, itchy, or stuffy nose

Less common but important to monitor:

• headache
• dizziness
• indigestion
• diarrhea

Serious side effects:

• racing heartbeats
• lower airway inflammation (bronchitis)
• thrush
• sudden worsening of breathing problems
• eye pain or swelling
• vision changes
• severe allergic reactions like rash, severe dizziness, or trouble breathing

Tiotropium is a medication commonly prescribed for chronic obstructive pulmonary disease (COPD) and asthma. While it is generally well-tolerated, it's important to be aware of potential interactions with other medications:

• Other Anticholinergic Drugs: Combining tiotropium with other anticholinergic medications, such as Ipratropium or certain antihistamines, can increase the risk of side effects like dry mouth, constipation, urinary retention, and blurred vision.

• Beta-Blockers: Caution is advised when using tiotropium alongside beta-blockers (e.g., Propranolol, Atenolol), as this combination may affect heart rate and respiratory function.

• Diuretics: Concurrent use of tiotropium with diuretics like Furosemide may increase the risk of low potassium levels (hypokalemia), potentially leading to heart rhythm issues.

• Tricyclic Antidepressants and Antipsychotics: These medications can enhance anticholinergic effects when taken with tiotropium, increasing the likelihood of side effects such as dry mouth and blurred vision.

• Cimetidine: This medication may increase tiotropium levels in the body, potentially leading to enhanced effects and side effects.

• Glucagon: Using glucagon with tiotropium can increase the risk of gastrointestinal side effects due to additive effects on inhibiting gastrointestinal motility.

• Pramlintide: Combining pramlintide with tiotropium may lead to enhanced anticholinergic effects, particularly affecting the gastrointestinal system.

It's essential to inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are currently taking to avoid potential interactions.