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The following safety guidelines and precautions are essential for the proper use of trifluridine (Viroptic), a medication prescribed for herpes eye infections. It is crucial to adhere to these instructions to minimize potential risks and ensure effective treatment. If you have any questions or concerns, please consult your healthcare provider.

• Potential Eye Damage: Trifluridine (Viroptic) should be used strictly as directed by your healthcare provider. Prolonged use, specifically more than 21 consecutive days, increases the risk of damage to the eye's surface. If there are no improvements in your symptoms, consult your prescriber rather than extending the duration of use.

• Specific Use for Herpes Eye Infection: This medication is specifically intended for the treatment of herpes infections in the eye, as diagnosed by a healthcare professional. It should not be used for other eye infections.

• Eye Irritation: Some users may experience mild and temporary irritation in or around the eye. If this irritation becomes bothersome or persists, it is important to inform your prescriber.

Currently, there are no contraindications listed for trifluridine (Viroptic). Always follow your healthcare provider’s instructions and report any unusual side effects or concerns you may have during your treatment.

Common side effects:

• Mild and temporary burning or stinging sensation
• Slight eyelid swelling

Less common but important to monitor:

• Eye irritation
• Dry eyes
• Excessive tearing
• Increase in eye pressure

Serious side effects:

• Swelling in the face or throat
• Rash
• Itching
• Severe dizziness
• Trouble breathing
• Significant eye pain
• Redness
• Vision changes

When taking trifluridine, it's important to be aware of potential interactions with other medications, as these can affect how the drug works or increase the risk of side effects. Here are some key considerations:

Blood Thinners: Combining trifluridine with anticoagulants like Warfarin may elevate the risk of bleeding.

Other Cancer Treatments: Using trifluridine alongside chemotherapy agents such as Fluorouracil or Capecitabine can heighten the likelihood of severe side effects, including bone marrow suppression.

Live Vaccines: Trifluridine can weaken the immune system. Receiving live vaccines (e.g., measles, mumps, and rubella) during treatment may increase the risk of contracting the infection the vaccine is designed to prevent.

Transporter Proteins: Trifluridine is processed in the body by certain transporter proteins. Medications that affect these proteins could potentially alter trifluridine levels, though the clinical significance of this is not well established.

Chloramphenicol: This antibiotic, when used with trifluridine, may increase the risk of bone marrow suppression, a serious condition affecting blood cell production.

It's also worth noting that trifluridine is not metabolized by the liver enzymes known as cytochrome P450 (CYP), so it's unlikely to interact with drugs that are processed by these enzymes.

Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking. They can help you navigate potential interactions and ensure your treatment plan is safe and effective.