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When using Valacyclovir (Valtrex), it is important to be aware of certain safety precautions and potential risks. Please review the following information and consult your healthcare provider with any questions or concerns.

• Blood Clotting Disorders: There is a risk of rare but serious blood disorders such as thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) when taking Valacyclovir (Valtrex), particularly at doses exceeding 8 grams per day. These conditions have been observed in individuals with HIV and those with weakened immune systems. Regular blood tests may be recommended by your healthcare provider to monitor your condition. Be alert for symptoms like abdominal pain, fever, unusual bleeding or bruising, fatigue, or blood in the urine, and report them to your provider immediately.

• Kidney Issues: Valacyclovir (Valtrex) can occasionally cause significant kidney problems. This risk is heightened in older adults and individuals taking other medications harmful to the kidneys. To mitigate this risk, ensure adequate fluid intake while on this medication. Contact your healthcare provider if you experience lower back pain, urination difficulties, or swelling in the extremities, as these may indicate kidney issues.

• Nervous System Effects: Some individuals may experience agitation, confusion, hallucinations, or seizures while taking Valacyclovir (Valtrex). These effects are more likely if you have kidney problems and are taking doses higher than recommended. If you or those around you notice such symptoms, consult your healthcare provider promptly as discontinuation of the medication may be necessary.

If you have any further questions or encounter any of these symptoms, it is crucial to seek medical advice promptly to ensure your safety while using Valacyclovir (Valtrex).

Common side effects:

• Nausea
• Headache
• Stomach pain
• Dizziness

Less common but important to monitor:

• Changes in the amount of urine
• Unusual back or side pain
• Agitation
• Confusion
• Hallucinations
• Shaky or unsteady movements
• Unusual tiredness
• Fast heartbeat
• Easy bruising or bleeding
• New fever
• Bloody or dark urine
• Severe stomach or abdominal pain
• Yellowing of the eyes or skin

Serious side effects:

• Sudden vision changes
• Trouble speaking
• Loss of consciousness
• Seizures
• Severe allergic reaction (rash, itching, swelling, severe dizziness, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Acyclovir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Dichlorphenamide
• Foscarnet
• Leflunomide
• Nitisinone
• Teriflunomide
• Fosphenytoin
• Phenytoin
• Valproic Acid

Interactions with low risk that usually do not require a change in therapy:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, Naproxen