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Valganciclovir

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generic Valcyte

Valganciclovir is an oral antiviral medication used to prevent and treat infections caused by the cytomegalovirus (CMV). It is particularly important for individuals who have received organ transplants to prevent CMV, and for people with advanced HIV (AIDS) to treat CMV retinitis—a serious eye infection that can lead to blindness. Once inside the body, valganciclovir is converted to its active form, ganciclovir. This active compound stops the CMV virus from replicating by inhibiting an enzyme called DNA polymerase, thus slowing the virus's growth and preventing the spread of infection. For prevention, the medication is generally taken once daily, but for treating an active CMV infection, it may be taken twice daily initially. Valganciclovir is available in tablet form and as an oral solution, with generic versions offering a cost-effective option. While valganciclovir helps manage CMV infections, it is not a cure. Regular eye examinations are crucial for those with CMV retinitis to monitor and manage the condition effectively. Common side effects may include diarrhea, fever, and fatigue. Always consult with a healthcare provider for personalized medical advice before starting this medication.
Our coupons are free to use. Before paying, show the pharmacist your Valganciclovir savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Valganciclovir prices will update based on your prescription needs. Above our Valganciclovir coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Valganciclovir at the lowest price with our prescription discount card.

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450MG, Valganciclovir (30 Tablets)

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CVS

$73.23

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$77.82

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$122.68

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$473.70

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Valganciclovir dosage forms

The average cost for 30 Tablets of Valganciclovir (generic Valcyte) at 450MG is $72.33 with a free coupon. This is 4.39% off the average retail price of $1646.4
DosageQuantityPrice fromPer unit
450MG30 Tablets$72.33$2.41

Valganciclovir Warnings

Valganciclovir is converted into ganciclovir within the body, which can have significant safety implications. It is crucial to be aware of the potential risks and necessary precautions associated with this medication. Below are key safety and warning considerations:

  • Blood and Bone Marrow Health: Valganciclovir can severely affect bone marrow function, resulting in reduced blood cell counts, which may lead to anemia, increased susceptibility to infections, and bleeding issues. Regular blood tests will be conducted by your healthcare provider to monitor these effects. Immediate medical attention is required if symptoms such as unusual fatigue, rapid breathing, pale skin, fast heartbeat, persistent sore throat, fever, chills, cough, easy bruising, nosebleeds, bleeding gums, or dark stools occur.

  • Fertility Concerns: This medication may impair fertility in both men and women, potentially causing lasting effects. Discuss family planning with your healthcare provider if you are considering having children.

  • Pregnancy Risks: Valganciclovir poses a risk to an unborn baby. Women should use effective contraception during treatment and for at least one month after discontinuation. Men should use condoms during treatment and for three months post-treatment to prevent harm to a partner's pregnancy.

  • Cancer Risks: Animal studies suggest that valganciclovir could be carcinogenic to humans. Disclose your full medical history to your healthcare provider before starting treatment.

  • Kidney Health: The drug may cause serious kidney damage, particularly in older adults, those who are dehydrated, or those taking other kidney-affecting medications. Ensure adequate hydration and consult your healthcare provider before introducing any new medications. Regular kidney function tests may be necessary, and dosage adjustments might be required if kidney health declines.

  • Contraindications: Do not use valganciclovir if you have had a severe allergic reaction to ganciclovir. Consult your healthcare provider if this applies to you.

In case of an overdose, seek emergency medical assistance immediately. Always discuss any concerns or questions with your healthcare provider to ensure safe use of valganciclovir.

Valganciclovir Side Effects

Common side effects:

  • Diarrhea
  • Nausea
  • Headache
  • Vomiting
  • Upset stomach
  • Dizziness
  • Drowsiness
  • Shakiness

Less common but important to monitor:

  • Difficulty sleeping
  • Stomach pain
  • Fever
  • Low blood cell counts
  • Kidney problems (indicated by lab results)

Serious side effects:

  • Mental or mood changes (confusion, hallucinations)
  • Signs of kidney problems (changes in urine output)
  • Seizures
  • Nerve pain in hands and feet
  • Tingling sensations
  • Eye pain
  • Chills
  • Loss of appetite
  • Back pain
  • Muscle pain
  • Cough
  • Night sweats
  • Severe allergic reaction (rash, itching, swelling of face, tongue, throat, severe dizziness, difficulty breathing)

Valganciclovir Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • ganciclovir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • imipenem/cilastatin
  • maribavir
  • cancer chemotherapy
  • trimethoprim/sulfamethoxazole
  • zidovudine
  • cyclosporine
Valganciclovir FAQs
What is the drug valganciclovir used for?

Valganciclovir is used to treat cytomegalovirus (CMV) infections, particularly in patients with weakened immune systems, such as those with HIV/AIDS or organ transplant recipients. It is also used to prevent CMV disease in high-risk organ transplant patients.

Valganciclovir is considered a hazardous drug because it has the potential to cause significant adverse effects, including teratogenicity (risk of causing birth defects), carcinogenicity (potential to cause cancer), and reproductive toxicity. It can also cause myelosuppression, leading to decreased blood cell counts, which can increase the risk of infections and bleeding. Due to these risks, special handling precautions are necessary to protect healthcare workers and patients.

Valcyte (valganciclovir) is not a chemotherapy drug. It is an antiviral medication used to treat cytomegalovirus (CMV) infections, particularly in people with weakened immune systems, such as organ transplant recipients.

Valganciclovir carries a black box warning for hematologic toxicity, carcinogenicity, teratogenicity, and impairment of fertility. It can cause severe leukopenia, neutropenia, anemia, thrombocytopenia, and pancytopenia. It is also considered a potential carcinogen and teratogen, and it may impair fertility. Patients should be monitored closely for these risks, and the drug should be used with caution in individuals with pre-existing hematologic conditions.

Acyclovir and valganciclovir are both antiviral medications, but they are used to treat different types of viral infections. Acyclovir is primarily used to treat infections caused by herpes viruses, such as herpes simplex virus (HSV) and varicella-zoster virus (VZV), which causes chickenpox and shingles. Valganciclovir, on the other hand, is used to treat cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those who have undergone organ transplants. Additionally, valganciclovir is a prodrug of ganciclovir, meaning it is converted into ganciclovir in the body, which is the active form of the medication.