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The following information outlines important safety and warning details related to the use of cidofovir. It is crucial to understand these potential risks and precautions. Always consult your healthcare provider if you have questions or concerns.

• Kidney Issues: Cidofovir can severely affect kidney function. The risk increases with dehydration or the use of other kidney-affecting medications, such as NSAIDs like ibuprofen and naproxen. Ensure adequate hydration during treatment, and discuss all medications, including OTC pain and cold remedies, with your healthcare provider. Kidney function will be monitored through lab tests within 48 hours of each dose. Any significant changes in kidney function may necessitate dosage adjustments or discontinuation.

• Reduced White Blood Cell Count: There is a possibility that cidofovir may lower your white blood cell count, increasing infection risk. Regular blood tests will be conducted to monitor this throughout the treatment.

• Fertility Concerns: Cidofovir can affect fertility in both males and females. Discuss any concerns about fertility with your healthcare provider.

• Pregnancy Risks: Cidofovir may cause harm to an unborn child if used during pregnancy. This risk extends to males using cidofovir whose partners may conceive. Females should use contraception during and for 30 days after treatment, while males should use condoms during and for 90 days post-treatment.

• Cancer Potential: Animal studies suggest that cidofovir could increase cancer risk in humans.

• Vision Changes: Some individuals may experience changes in eye pressure, which can result in decreased vision or eye inflammation. Report any vision changes to your healthcare provider immediately.

Please adhere to these guidelines and maintain open communication with your healthcare provider for safe usage of cidofovir.

Common side effects:

• Protein in the urine
• Low white blood cell count
• Changes in eye pressure
• Fever
• Infections

Less common but important to monitor:

• Shortness of breath
• Nausea or vomiting

When taking cidofovir, it's crucial to be aware of potential drug interactions that can affect your kidney health and overall treatment effectiveness. Cidofovir itself can be hard on the kidneys, so combining it with other medications that also impact kidney function can increase the risk of serious side effects.

Medications to Avoid:

• Nephrotoxic Agents: Avoid using cidofovir with drugs known to harm the kidneys, such as:

  • Aminoglycoside antibiotics (e.g., Amikacin, gentamicin, Tobramycin)
  • Amphotericin B
  • Foscarnet
  • Intravenous pentamidine
  • Vancomycin
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Naproxen

  These medications should be stopped at least seven days before starting cidofovir to reduce the risk of kidney damage.

• Probenecid: While probenecid is often given with cidofovir to help protect the kidneys, it can interact with other medications. For example, if you're taking Zidovudine, your doctor may adjust the dose or advise you to stop it temporarily on the days you receive cidofovir and probenecid.

Other Considerations:

• Diuretics: Medications that increase urine production, like Hydrochlorothiazide or Furosemide, can also affect kidney function. It's recommended to discontinue these drugs at least seven days before starting cidofovir.

• Antiviral Medications: Drugs such as Tenofovir Disoproxil Fumarate may increase the risk of kidney problems when used with cidofovir. If combined use is necessary, your doctor will closely monitor your kidney function.

Always inform your healthcare provider about all the medications you're taking, including over-the-counter drugs and supplements, before starting cidofovir. This will help them manage potential interactions and ensure your treatment is both safe and effective.