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This medication comes with important safety considerations that users should be aware of. Below are the key warnings and precautions to ensure safe use. Please review them and consult your healthcare provider with any questions or concerns.

• Risk of Bowel Obstruction: Cholestyramine (Prevalite) may lead to constipation, potentially causing severe issues such as bowel obstruction, especially in individuals with existing digestive tract conditions like bile duct, stomach, or intestinal blockages. Notify your healthcare provider promptly if you experience severe abdominal pain or constipation.

• Increased Bleeding Risk: Long-term use of cholestyramine (Prevalite) can elevate the risk of bleeding. It's crucial to inform your healthcare provider immediately if you notice symptoms such as vomiting blood, blood in your urine, black or tarry stools, bleeding gums, or unexplained bruising.

• Constipation Concerns: This medication may cause or worsen constipation. To alleviate this, increase fluid intake, exercise, or include more fiber in your diet. Discuss with your healthcare provider the possibility of using a stool softener or laxative if needed. Risk factors include heart disease, high dosages, and age over 60.

• Dental Issues: Holding or sipping this medication for extended periods can discolor teeth, erode tooth enamel, or cause tooth decay. Regular brushing and dental check-ups are advised.

• Drug Interactions: Cholestyramine (Prevalite) binds bile acids in the gut, which may interfere with the absorption of other medications. It is advised to take other medications at least 1 hour before or 4 to 6 hours after cholestyramine to prevent absorption issues. Consult your healthcare provider or pharmacist for guidance on medication scheduling.

• Low Folic Acid Levels: Prolonged use may result in reduced folic acid levels, which are vital for forming red and white blood cells. Symptoms of low folic acid include fatigue, weakness, pale skin, loss of appetite, rapid heartbeat, and shortness of breath. Discuss with your healthcare provider about taking folic acid supplements if necessary.

• Vitamin Absorption Issues: This medication can decrease the absorption of fat-soluble vitamins (A, D, E, and K). Consider discussing vitamin supplementation or dosage adjustments with your healthcare provider. If you take daily vitamins, it's best to consume them 1 hour before or at least 4 hours after cholestyramine.

• Phenylketonuria (PKU) Warning: Cholestyramine (Prevalite) contains phenylalanine, which may not be suitable for individuals with PKU due to potential complications. Consult your healthcare provider to explore safer alternatives if you have a history of phenylketonuria.

In case of an overdose or severe adverse effects, seek immediate medical attention. Always follow your healthcare provider's instructions and inform them of any concerns or unusual symptoms.

Common side effects:

• Constipation
• Stomach discomfort
• Nausea
• Vomiting
• Diarrhea
• Bloating or gas

Serious side effects:

• Severe constipation
• Intense stomach pain
• Unusual bruising or bleeding
• Bloody, black, or tarry stools
• Allergic reactions (skin rash, itching or swelling, severe dizziness, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Warfarin
• Anisindione
• Dicumarol
• Phenprocoumon

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Mycophenolate
• Mycophenolate Mofetil
• Mycophenolic Acid
• Raloxifene
• Bezafibrate
• Deferasirox
• Dexamethasone
• Digoxin
• Aceclofenac
• Cephalexin
• Cerivastatin
• Diclofenac
• Digitoxin
• Ezetimibe
• Furosemide
• Hydrochlorothiazide
• Levothyroxine
• Meloxicam
• Metronidazole
• Propranolol
• Valproic Acid