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This medication comes with important safety warnings that should be carefully reviewed. If you have any concerns, please discuss them with your healthcare provider.

• Severe Muscle Pain and Damage: Lovastatin can occasionally cause a serious condition called rhabdomyolysis, which involves severe muscle damage and can lead to kidney issues. Those at higher risk include individuals over 65, those on higher doses of lovastatin, and those with kidney problems or taking other muscle-impacting medications. Seek immediate medical help if you experience severe muscle pain, tenderness, weakness, dark urine, or unusual fatigue.

• Liver Issues: Some individuals taking lovastatin have experienced changes in liver enzyme levels, potentially indicating liver damage. These changes may occur within the first year of use, and in rare cases, severe liver problems leading to liver failure can develop. The risk increases if there is a history of liver issues or excessive alcohol consumption.

• Elevated Blood Sugar Levels: Research indicates that lovastatin may increase blood sugar levels, affecting hemoglobin A1C. It's important to inform your healthcare provider if you have diabetes or elevated blood sugar before starting lovastatin. You may need to monitor your blood sugar more frequently and maintain a healthy diet and exercise routine.

• Pregnancy and Breastfeeding Risks: Lovastatin is generally not recommended during pregnancy or breastfeeding due to potential risks to the unborn or breastfed child. Consult your healthcare provider for safer alternatives if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications: This medication should not be used in certain conditions due to serious health risks. Consult your healthcare provider if you have:

• Liver issues, such as liver failure or severe cirrhosis
• Currently pregnant or breastfeeding
• Are taking medications that may interact with lovastatin

Common side effects:

• Gas
• Constipation
• Nausea
• Stomach pain
• Headaches
• Muscle pain

Less common but important to monitor:

• Muscle tenderness
• Weakness
• Cramps
• Indigestion

Serious side effects:

• Rhabdomyolysis
• Liver problems
• Allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Clarithromycin
• Erythromycin
• Itraconazole
• Ketoconazole
• Ritonavir
• Cobicistat
• Telithromycin
• Amprenavir
• Atazanavir
• Boceprevir
• Darunavir
• Fosamprenavir
• Idelalisib
• Indinavir
• Mibefradil
• Mifepristone
• Nefazodone
• Nelfinavir
• Posaconazole
• Saquinavir
• Telaprevir
• Tipranavir
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiodarone
• Cyclosporine
• Colchicine
• Gemfibrozil
• Daptomycin
• Bezafibrate
• Ceritinib
• Ciprofibrate
• Clofibrate
• Conivaptan
• Dabigatran Etexilate
• Dalfopristin
• Danazol
• Delavirdine
• Diltiazem
• Dronedarone
• Duvelisib
• Fenofibrate
• Fenofibric Acid
• Fluconazole
• Fosnetupitant
• Glecaprevir
• Ivosidenib
• Larotrectinib
• Lefamulin
• Letermovir
• Lomitapide
• Lorlatinib
• Lumacaftor
• Netupitant
• Niacin
• Pibrentasvir
• Quinupristin
• Ranolazine
• Verapamil

Interactions with low risk that usually do not require a change in therapy:

• Azithromycin
• Bosentan
• Clopidogrel
• Oat Bran
• Pectin
• St John's Wort