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When using cholestyramine (Prevalite), it is important to be aware of the following safety warnings and precautions. If you have any concerns or questions, please consult with your healthcare provider.

• Bowel Obstruction or Blockage: Cholestyramine may cause constipation, which can lead to severe digestive issues such as bowel obstruction, particularly in individuals with pre-existing conditions like bile duct, stomach, or intestinal blockages. If you experience severe abdominal pain or constipation, contact your healthcare provider immediately.

• Increased Bleeding Risk: Long-term use of cholestyramine may increase the risk of bleeding. Be vigilant for any signs of bleeding, such as vomiting blood, blood in urine, black or tarry stools, unexplained bruising, or bleeding gums, and report them to your healthcare provider without delay.

• Constipation: This medication may cause or exacerbate constipation. To help alleviate this, increase your fluid intake, engage in regular exercise, and consider adding fiber to your diet. Discuss with your healthcare provider the possibility of using a stool softener or laxative if constipation remains a concern, especially if you have heart disease, are taking high doses, or are over 60 years old.

• Dental Issues: Prolonged contact of cholestyramine with your teeth can lead to discoloration, enamel erosion, or decay. It is important to brush your teeth regularly and visit your dentist for routine check-ups.

• Drug Interactions: Cholestyramine may interfere with the absorption of other medications. To minimize this risk, take other medications at least 1 hour before or 4 to 6 hours after taking cholestyramine. Consult with your healthcare provider or pharmacist about the proper timing for taking your medicines.

• Low Folic Acid Levels: Prolonged use of cholestyramine can result in decreased folic acid levels, which are crucial for producing red and white blood cells. Symptoms of low folic acid might include fatigue, weakness, pale skin, loss of appetite, rapid heartbeat, and shortness of breath. Discuss the need for folic acid supplements with your healthcare provider.

• Vitamin Absorption: Cholestyramine may reduce the absorption of fat-soluble vitamins such as A, D, E, and K. Consider discussing vitamin supplementation with your healthcare provider, and if you take a daily vitamin, do so 1 hour before or at least 4 hours after cholestyramine.

• Phenylketonuria (PKU): Cholestyramine contains phenylalanine, and may not be suitable for individuals with PKU due to potential complications. Consult your healthcare provider for safer alternatives if you have a history of PKU.

Always follow your healthcare provider's guidance and report any unusual symptoms or concerns as soon as they arise.

When taking this medication, some individuals may experience mild side effects like constipation, stomach discomfort, nausea, vomiting, and gas. These effects are generally not a cause for concern, but if they persist or become bothersome, it's advisable to speak with a healthcare provider. To help alleviate constipation, incorporating dietary fiber, staying hydrated, and regular exercise are beneficial. A suitable laxative might also be recommended by a pharmacist.

In rare cases, more severe side effects can occur and should be addressed immediately. These include severe stomach pain, unusual bleeding or bruising, rapid breathing, and confusion. Additionally, severe constipation and bloody, black, or tarry stools are serious and require prompt medical attention. An allergic reaction to this medication is very uncommon but can manifest as a rash, itching or swelling, severe dizziness, and difficulty breathing. If any of these symptoms occur, seek medical help right away.

While most users do not experience severe side effects, it is important to remain vigilant and communicate any concerns to a healthcare professional. If you encounter any side effects not listed here, reaching out to a healthcare provider for advice is recommended.

Cholestyramine (Prevalite) can interact with several medications, affecting their effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and supplements.

Some medications that might interact with Cholestyramine include blood thinners like Warfarin and Dicumarol, which might require dose adjustments due to potential side effects or changes in efficacy. Additionally, medications such as Mycophenolate, Bezafibrate, and Digoxin may also interact with Cholestyramine, potentially necessitating changes in dosage or frequency of use.

While some interactions may lead to increased side effects, your healthcare provider may determine that the benefits of using both medications together outweigh the risks. Always follow the guidance of your doctor regarding medication adjustments and management.