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The following safety information outlines crucial precautions and potential risks associated with the use of cholestyramine (Prevalite). It is essential to review this guidance and discuss any concerns with your healthcare provider.

• Bowel Obstruction or Blockage: Cholestyramine may cause constipation, which can lead to severe conditions such as bowel obstruction, especially in individuals with existing digestive system issues. Notify your healthcare provider if you experience severe abdominal pain or constipation.

• Increased Bleeding Risk: Prolonged use of cholestyramine may increase the risk of bleeding. Report any signs of bleeding, such as vomiting blood, blood in urine, black or tarry stools, bleeding gums, or unexplained bruises, to your healthcare provider immediately.

• Constipation: This medication may cause or exacerbate constipation. To alleviate this, increase fluid intake, engage in physical activity, and incorporate more fiber into your diet. Consult your healthcare provider about using stool softeners or laxatives if needed.

• Dental Issues: Holding cholestyramine in your mouth can discolor teeth, erode enamel, or cause decay. Maintain oral hygiene by brushing regularly and visiting your dentist frequently.

• Medication Interactions: Cholestyramine may interfere with the absorption of other drugs. Take other medications at least 1 hour before or 4 to 6 hours after cholestyramine to avoid interaction. Consult your healthcare provider or pharmacist for guidance on timing your medications.

• Low Folic Acid Levels: Long-term use of cholestyramine can deplete folic acid, affecting red and white blood cell production. Symptoms include fatigue, weakness, pale skin, loss of appetite, rapid heartbeat, and shortness of breath. You may need folic acid supplements; consult your healthcare provider if you have concerns.

• Vitamin Interactions: Cholestyramine may reduce the absorption of fat-soluble vitamins (A, D, E, K). Discuss the need for vitamin supplements with your healthcare provider and adjust your doses as necessary. If you take daily vitamins, do so 1 hour before or at least 4 hours after cholestyramine.

• Phenylketonuria (PKU): Cholestyramine contains phenylalanine, which may not be suitable for individuals with PKU, as it can pose serious health risks. Discuss safer alternatives with your healthcare provider if you have a history of PKU.

When taking this medication, some individuals may experience common side effects such as mild constipation, stomach discomfort, nausea, vomiting, and gas or bloating. These symptoms are usually mild but should be discussed with a healthcare provider if they persist or worsen. To help manage constipation, it's advisable to increase dietary fiber intake, drink plenty of water, and engage in regular exercise. A suitable laxative might also be recommended by your pharmacist.

There are also some other side effects that, although less common, warrant attention. These include severe constipation, severe stomach pain, unusual bruising or bleeding, and changes in stool appearance, such as bloody, black, or tarry stools. If any of these occur, or if you experience rapid breathing or confusion, it is important to contact your healthcare provider promptly.

Allergic reactions to this medication are rare but can be serious. If you notice symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing, seek immediate medical assistance. Always stay vigilant about how you feel during treatment and report any unexpected changes to your healthcare provider.

Cholestyramine (Prevalite) can interact with various medications, and it's important to inform your doctor and pharmacist about all the medicines and supplements you are currently using. This includes any prescription, over-the-counter drugs, vitamins, and herbal supplements.

Some medications that may interact with Cholestyramine include blood thinners like [Warfarin](https://savehealth.com/warfarin), as well as Mycophenolate and Raloxifene. Additionally, there can be interactions with bezafibrate, Deferasirox, Dexamethasone, Digoxin, mycophenolate mofetil, and Mycophenolic Acid. These interactions might require adjustments in how you take one or both medicines.

Furthermore, using Cholestyramine with certain other drugs could increase the risk of side effects. These drugs include aceclofenac, anisindione, Cephalexin, cerivastatin, Diclofenac, dicumarol, digitoxin, Ezetimibe, Furosemide, Hydrochlorothiazide, Levothyroxine, Meloxicam, Metronidazole, phenprocoumon, Propranolol, Valproic Acid, and warfarin. In some situations, the benefits of using both medicines together might outweigh the risks, so your doctor may adjust doses or usage frequency accordingly. Always consult your healthcare provider for guidance tailored to your health needs.