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The following safety and warning information outlines critical considerations when using cholestyramine (Prevalite). These details are vital for managing potential risks and ensuring effective use of the medication. If you have any questions or concerns, please consult your healthcare provider.

• Bowel Obstruction or Blockage: Cholestyramine can cause constipation, which may lead to serious complications, such as bowel obstruction, especially in individuals with existing digestive tract issues. If you experience severe stomach pain or constipation, notify your healthcare provider immediately.

• Increased Risk of Bleeding: Long-term use of cholestyramine may increase the risk of bleeding. If you notice signs such as vomiting blood, blood in your urine, black or tarry stools, bleeding gums, or unexplained bruising, contact your healthcare provider without delay.

• Constipation Concerns: The medication can cause or exacerbate constipation. Increasing fluid intake, regular exercise, and dietary fiber may alleviate symptoms. Consult your healthcare provider about the use of stool softeners or laxatives if constipation persists. Individuals with heart disease, those taking high doses, or those over 60 years old may be at heightened risk.

• Dental Issues: Holding the medication in your mouth for extended periods or sipping it can discolor teeth, damage enamel, or cause tooth decay. Maintain good oral hygiene by brushing your teeth regularly and visiting a dentist frequently.

• Drug Interactions: Cholestyramine may interfere with the absorption of other medications due to its action in the gut. To minimize this effect, take other medications at least 1 hour before or 4 to 6 hours after cholestyramine. Consult your healthcare provider or pharmacist about any necessary adjustments to your medication schedule.

• Low Folic Acid Levels: Prolonged use of cholestyramine can result in low folic acid levels, which are essential for forming red and white blood cells. Symptoms of deficiency include fatigue, weakness, pale skin, loss of appetite, rapid heartbeat, and shortness of breath. Discuss the need for folic acid supplements with your healthcare provider.

• Vitamin Absorption Issues: The medication may reduce the absorption of fat-soluble vitamins (A, D, E, and K). Consider vitamin supplementation or dosage adjustments after consulting with your healthcare provider. If you take a daily vitamin, do so 1 hour before or at least 4 hours after taking cholestyramine.

• Phenylketonuria (PKU): Cholestyramine contains phenylalanine, which may not be suitable for individuals with PKU due to potential complications. Discuss alternative treatment options with your healthcare provider if you have a history of PKU.

When taking this medication, some individuals may experience mild side effects such as constipation, stomach discomfort, nausea, vomiting, diarrhea, bloating, or gas. These effects are generally not severe and often improve over time. To alleviate constipation, consider increasing your dietary fiber intake, staying hydrated, and engaging in regular exercise. If necessary, consult a pharmacist to choose a suitable laxative.

However, if you notice any severe side effects, it is important to seek medical advice promptly. These may include severe stomach pain, unusual bleeding or bruising, or severe constipation. Additionally, observe for signs of an allergic reaction, such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. While an allergic reaction to this medication is rare, immediate medical attention is crucial if symptoms arise.

Remember, the side effects listed here are not exhaustive. If you experience any other unusual symptoms, do not hesitate to contact your healthcare provider.

Cholestyramine (Prevalite) can interact with various medications, so it's crucial to inform your doctor and pharmacist about all the drugs and supplements you're taking, including over-the-counter products, vitamins, and herbal supplements. Here are some important interaction details:

1. Medications that usually require caution: While it is generally advised to avoid using cholestyramine with certain medications unless necessary, a healthcare provider might adjust dosages or the frequency of use if both are prescribed together. These medications include Bezafibrate, Deferasirox, Dexamethasone, Digoxin, Mycophenolate Mofetil, and Mycophenolic Acid.

2. Medications with increased side effect risk: Combining cholestyramine with these drugs might heighten the risk of side effects. However, the combination might still be recommended as it could offer the best treatment approach. In such cases, your healthcare provider might modify the dosage or usage schedule. These drugs include Aceclofenac, Anisindione, Cephalexin, Cerivastatin, Diclofenac, Dicumarol, Digitoxin, Ezetimibe, Furosemide, Hydrochlorothiazide, Levothyroxine, Meloxicam, Metronidazole, Phenprocoumon, Propranolol, Valproic Acid, and Warfarin.

Always consult your healthcare provider before making any changes to your medication regimen.