Zuplenz

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Ondansetron, commonly known as Zofran, is an antiemetic medication used to prevent nausea and vomiting associated with cancer treatments such as chemotherapy and radiation, as well as after surgical procedures. It functions by blocking serotonin, a natural substance in the body that can lead to nausea and vomiting. Ondansetron is available in various forms, including orally disintegrating tablets, oral solution, and injections administered by healthcare professionals. Common side effects may include headache, fatigue, and changes in bowel movements such as constipation or diarrhea. Always consult with your healthcare provider before starting any new medication.
Our Zuplenz coupons are free to use. You can print the coupon, email it to yourself, or receive the Zuplenz coupon via text message. To get your free discount, show the pharmacist your Zuplenz savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Zuplenz prices will update based on your prescription needs. Above our Zuplenz coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Zuplenz savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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4MG, Zuplenz (30 Films)

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CVS

$1062.92

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$1047.62

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Zuplenz dosage forms

The average cost for 30 Films of Zuplenz at 4MG is $1062.92 with a free coupon. This is 27.93% off the average retail price of $3804.99
DosageQuantityPrice fromPer unit
4MG30 Films$1062.92$35.43
8MG30 Films$1062.92$35.43

Zuplenz Warnings

When using ondansetron (Zofran), it is crucial to be aware of the following safety warnings and contraindications. Please read them thoroughly and discuss any concerns with your healthcare provider.

  • Severe Allergic Reactions: Some individuals may experience life-threatening allergic reactions, such as facial swelling, hives, and anaphylaxis. Be alert for symptoms like dizziness, rapid heartbeat, difficulty breathing, or swelling around the face. Seek immediate medical attention if these occur.

  • QT Prolongation (Abnormal Heart Rhythm): Ondansetron can lead to serious heart rhythm issues, particularly QT prolongation, which affects the heart's pumping and relaxation cycle. Those with abnormal electrolyte levels, existing heart rhythm problems, or who are taking certain medications (e.g., amiodarone, ciprofloxacin) are at increased risk. Regular heart monitoring and EKGs may be recommended. Contact emergency services if you experience chest pain, pounding heart, shortness of breath, or faintness.

  • Serotonin Syndrome: This rare but serious condition can develop when ondansetron is taken with other medications that elevate serotonin levels, such as certain antidepressants and migraine medications. Monitor for symptoms if using these drugs together.

  • Risk of Heart Attack: In rare cases, ondansetron has been associated with heart attacks, especially when administered via injection. If you experience chest or arm pain, tightness, or difficulty breathing, seek emergency medical help.

  • Masking of Gut Issues: Ondansetron may conceal symptoms of gut blockage or bloating in individuals who have recently had stomach surgery or are undergoing chemotherapy. Report any irregularities in bowel movements or gas passage to your healthcare provider.

  • Phenylketonuria (PKU) Caution: The orally disintegrating tablets (ODTs) contain phenylalanine, which is unsafe for individuals with PKU. Inform your provider if you have this genetic condition to explore alternative formulations.

Contraindications:

  • Concurrent Use with Apomorphine: Avoid using ondansetron while taking apomorphine (Apokyn) due to the risk of severe hypotension and loss of consciousness.

Always consult with your healthcare provider to ensure safe usage based on your specific health conditions and medications.

Zuplenz Side Effects

When taking this medication, some people may experience mild side effects like headaches, fatigue, constipation, or diarrhea. These are common and usually not a cause for worry, but if they persist or worsen, consulting a healthcare provider is advised. Other mild side effects can include dizziness, anxiety, itchy skin, and rashes. It's important to note that many individuals using this medication do not experience serious side effects.

However, there are rare but serious side effects that require immediate medical attention. These include severe allergic reactions characterized by hives, breathing difficulties, or swelling of the face, lips, tongue, or throat. Additionally, abnormal heart rhythms may manifest as chest pain, irregular heartbeat, shortness of breath, or feelings of faintness or lightheadedness. In very rare cases, a heart attack is possible.

Another serious condition, serotonin syndrome, can occur if the medication is taken alongside other drugs that increase serotonin. Symptoms include a rapid heart rate, severe dizziness, sweating, muscle twitching or stiffness, uncoordinated movements, and hallucinations. If any of these severe symptoms occur, seek urgent medical help. Always discuss any other medications you are taking with your healthcare provider to reduce the risk of these interactions.

Zuplenz Interactions

When taking Ondansetron (Zofran), it's important to be aware of potential drug interactions. This medication should not be combined with certain drugs such as apomorphine due to possible severe reactions. Additionally, using Ondansetron with medications like tramadol, certain antidepressants (including SSRIs like fluoxetine or paroxetine, and SNRIs like duloxetine or venlafaxine), or supplements like St. John's wort can increase the risk of serotonin syndrome, a potentially dangerous condition. This risk is heightened when you start or increase the dosage of these drugs. Always inform your healthcare provider about any other medications or supplements you are taking to avoid harmful interactions.
Zuplenz FAQs
Is Zuplenz discontinued?

Yes, Zuplenz has been discontinued.

Zuplenz is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It contains the active ingredient ondansetron, which works by blocking the actions of chemicals in the body that can trigger nausea and vomiting.

The generic name for Zuplenz is ondansetron.