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It is crucial to be aware of the following safety information and warnings related to the use of Sancuso (granisetron). Please consider these details seriously and reach out to your healthcare provider with any questions or concerns.

• Digestive Concerns: There have been instances of severe constipation in patients using Sancuso. This medication may also obscure symptoms of intestinal blockage or bloating. Monitor your bowel movements closely and consult your healthcare provider if you experience constipation, difficulty passing gas, or abdominal pain and swelling. This risk is heightened for individuals who have undergone abdominal surgery or are taking opioid medications.

• Serotonin Syndrome: This is a rare yet serious condition characterized by excessive serotonin activity in the brain, potentially becoming life-threatening. The risk increases when Sancuso is used alongside other medications that influence serotonin levels, such as antidepressants, lithium, or certain herbal supplements like St. John's Wort. Symptoms to watch for include rapid heartbeat, sweating, muscle stiffness or spasms, fever, and confusion. Promptly inform your healthcare provider if you notice any of these symptoms.

• Skin Reactions: The area of skin under and surrounding the patch may become irritated. If skin reactions intensify, it is advisable to remove the patch.

• Exposure to Heat and Sun: Increased body absorption of Sancuso may occur due to heat and direct sunlight, and skin reactions can happen even after the patch is removed. Avoid heat pads and other heat sources near the patch. Additionally, protect the patch and your skin from direct sunlight by wearing clothing that covers your upper arms.

Please ensure that you follow these guidelines to minimize risks and maximize the effectiveness of your treatment.

When taking this medication, some people might experience constipation. While this is generally a minor issue, it's important to let your healthcare provider know if it persists or worsens. Most users do not encounter serious side effects, which can be reassuring.

However, be aware of rare but significant side effects. If you experience severe stomach or abdominal pain or swelling, seek medical attention promptly. There is also a risk, albeit low, of developing serotonin syndrome, a serious condition that occurs when serotonin levels become too high. This risk is heightened if you are on other serotonin-enhancing drugs. Watch for symptoms like a rapid heartbeat, hallucinations, loss of coordination, severe dizziness, intense nausea or vomiting, twitching muscles, unexplained fever, or unusual agitation. Seek immediate medical help if these occur.

Additionally, though extremely rare, serious allergic reactions can happen. Be vigilant for signs such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. If these symptoms arise, it's critical to get emergency medical help.

This summary does not cover all potential side effects, so if you notice any other unusual symptoms, contact your healthcare provider for guidance.

When taking Sancuso (granisetron), it's important to be aware of potential drug interactions. You should inform your healthcare provider about all the medications and supplements you're currently using, including prescription, non-prescription, vitamins, and herbal products.

Certain drugs, such as apomorphine, should not be used with Sancuso due to significant interaction risks. Additionally, the risk of developing serotonin syndrome—a serious condition—can increase if you're using other medications that boost serotonin levels. These include recreational drugs like MDMA ("ecstasy"), herbal supplements like St. John's wort, and specific antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine). This risk is particularly notable when you start or increase the dosage of these medications.

Moreover, there are several other drugs that may not be recommended for concurrent use with Sancuso, including but not limited to bepridil, cisapride, dronedarone, and Fluconazole. For some drugs, such as alfentanil, Amiodarone, and many others, concurrent use might still be considered necessary. In such cases, your doctor might adjust the dosages or frequency to minimize any potential interactions.

Lastly, using Sancuso with Phenobarbital may lead to heightened side effects, but it could be deemed necessary for your treatment plan. Your doctor will carefully manage your treatment to ensure safety and efficacy. Always consult your healthcare provider before making any changes to your medication regimen.