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When taking this medication, you may experience some common side effects such as diarrhea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping, or anxiety. These effects are usually mild, but if they persist or worsen, contact your healthcare provider for guidance.

Be aware of serious side effects that require immediate medical attention, such as unusual muscle movements or stiffness. It is crucial to seek urgent care if you experience very serious symptoms like chest pain, a fast or irregular heartbeat, severe dizziness, or fainting.

Additionally, this medication can increase serotonin levels, potentially leading to a rare but serious condition known as serotonin syndrome. The risk is higher if you are taking other medications that affect serotonin. Contact a healthcare professional immediately if you notice symptoms like a fast heartbeat, hallucinations, loss of coordination, severe nausea, vomiting, diarrhea, muscle twitching, unexplained fever, or unusual agitation.

Although a severe allergic reaction is rare, it is important to get emergency help if you experience symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. This summary does not include all possible side effects, so if you notice any other unusual symptoms, consult your healthcare provider.

Certain medications can interact with this drug. For example, apomorphine may have an interaction. Additionally, several medications, apart from granisetron, can impact heart rhythm, leading to QT prolongation. These include amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and certain antibiotics like erythromycin.

Furthermore, using other drugs that elevate serotonin levels can heighten the risk of serotonin syndrome or toxicity. This risk is present with substances like MDMA (commonly known as "ecstasy"), St. John's wort, and specific antidepressants such as SSRIs (e.g., fluoxetine, paroxetine) and SNRIs (e.g., duloxetine, venlafaxine). The chance of experiencing serotonin syndrome or toxicity might increase when starting these medications or upping their dosage.