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This medication has several important safety warnings and precautions that you need to be aware of before use. Please read the following information carefully and consult with your healthcare provider if you have any questions or concerns.

• Abnormal Sleep Behaviors: This drug may cause activities such as sleepwalking, sleep-driving, or sleep-eating without full awareness. You might also make phone calls or engage in sexual activities without remembering. These behaviors can be dangerous, potentially leading to serious harm or even fatalities. If you experience any of these actions, stop taking the medication immediately and contact your healthcare provider. It is important to avoid taking this medication with alcohol or other sedatives, as these can increase the risk of such behaviors.

• Daytime Drowsiness and Reduced Alertness: Using this medication can lead to feeling sleepy, dizzy, or confused during the day, especially when taken with alcohol, benzodiazepines, opioids, or tricyclic antidepressants. Inform your healthcare provider if you are using any of these substances, as your dose may need adjustment. Ensure you have 7 to 8 hours of sleep when taking this medication to minimize these effects.

• Severe Allergic Reactions: Rarely, this medication can cause a severe allergic reaction known as angioedema, which includes swelling of the tongue, lips, throat, or mouth, and trouble breathing. If you experience these symptoms, seek emergency medical attention immediately.

• Changes in Thoughts and Behavior: Some individuals may experience unusual thoughts or behavioral changes, including aggression, agitation, or hallucinations. Notify your healthcare provider if you experience any of these symptoms for proper evaluation.

• Slowed Breathing: This medication may cause slowed breathing, particularly in individuals with sleep apnea. If you notice changes in your breathing pattern, contact your healthcare provider as an alternative medication may be necessary.

• Liver Implications: For those with liver conditions, this medication may not be processed as efficiently, increasing the risk of side effects. It is contraindicated in severe liver problems due to the risk of brain damage. Inform your healthcare provider of any liver issues before starting this medication.

• Withdrawal Symptoms: Prolonged use can lead to tolerance and dependency, and stopping abruptly or reducing the dose can cause withdrawal symptoms such as nausea, vomiting, and anxiety. Report any withdrawal symptoms to your healthcare provider for management.

• Contraindications: Do not use this medication if you have experienced abnormal sleep behaviors, such as sleepwalking or sleep-driving, after taking it.

Ensure you discuss any pre-existing conditions or concurrent medication use with your healthcare provider to determine the safest course of action.

When taking this medication, some individuals may experience common side effects such as headache, sleepiness, dizziness, or diarrhea. These effects are usually mild, but if they persist or worsen, it is advisable to consult with a healthcare provider. Occasionally, other side effects might occur, including nausea, dry mouth, back pain, flu-like symptoms, chest pain, fatigue, lightheadedness, abnormal dreams, memory loss, stomach pain, constipation, sinus infection, sore throat, or rash. While they may be uncomfortable, most are not serious.

However, there are rare but serious side effects that require immediate medical attention. These include unusual sleep behaviors like sleepwalking or sleep driving, slowed brain activity leading to excessive sleepiness or confusion, and respiratory issues such as shallow or slow breathing. Additionally, serious allergic reactions may occur, characterized by itchy rashes, swelling of the face or throat, and difficulty breathing. If you experience any of these symptoms, seek urgent medical care. Suicidal thoughts or behavior changes are also critical to address promptly with a healthcare professional. Always be vigilant and report any severe or unexpected side effects to your healthcare provider.

Zolpidem may interact with a variety of other medications and supplements. It is important to inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Certain medications should not be combined with zolpidem. These include sodium oxybate, as well as other forms like calcium, magnesium, and potassium oxybate. Using these medications together is generally discouraged, and your doctor may advise against taking zolpidem or may modify your treatment plan.

There are medications that can increase the risk of serious side effects when taken with zolpidem. These side effects can include slowed breathing, severe drowsiness, or dizziness. Such medications include opioid pain relievers (e.g., codeine, hydrocodone), sleep or anxiety medications (e.g., Alprazolam, Lorazepam), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), and certain antihistamines (e.g., Cetirizine, diphenhydramine). Additionally, substances like alcohol and marijuana may also increase these risks.

Other medications, such as azole antifungals (e.g., Ketoconazole), Rifampin, and St. John's Wort, can affect how zolpidem is removed from your body, potentially altering its effectiveness.

Always check with your pharmacist or doctor before using any new medication or supplement, and read the labels of all your medicines, especially those for allergies or colds, as they may contain ingredients that cause drowsiness.