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When using zaleplon (Sonata), it is crucial to be aware of potential risks and take necessary precautions. Below is a summary of important safety information:

• Unusual Sleep Activities: Some individuals have engaged in activities like driving, cooking, or making phone calls while not fully awake, often without memory of these actions. If you experience such events, consult your healthcare provider immediately. Avoid using this medication, or similar ones like eszopiclone and zolpidem, if you have such reactions.

• Risk of Dependence: Zaleplon is a controlled substance that may lead to dependence, especially in those with a history of substance abuse. Use caution and seek medical advice if insomnia persists beyond 10 days of treatment, as this may indicate an underlying condition. Discuss alternative sleep strategies with your healthcare provider.

• Withdrawal Symptoms: Abruptly stopping zaleplon can cause withdrawal symptoms such as nausea, vomiting, and agitation. If you wish to discontinue use, consult your healthcare provider for a safe cessation plan.

• Next Day Drowsiness: Zaleplon may impair concentration and alertness into the following day. Older adults are particularly at risk of falls. Avoid engaging in activities requiring full alertness, like driving, until you understand how the drug affects you.

• Interactions with CNS Depressants: Zaleplon can interact with medications that depress the central nervous system, including antihistamines and alcohol, potentially worsening side effects. Inform your healthcare provider about all medications you are taking and report any unusual changes in behavior.

Always consult your healthcare provider if you have any concerns or experience adverse effects while taking zaleplon (Sonata).

Common side effects:

• Dizziness
• Drowsiness
• Lightheadedness
• "Pins and needles" sensation on the skin

Less common but important to monitor:

• Mental or mood changes like agitation
• Confusion
• Hallucinations
• Unusual behaviors
• Memory loss
• Severe anxiety
• Withdrawal symptoms like nausea, vomiting, sweating, stomach and muscle cramps, agitation, and seizures
• Engaging in unusual activities while not fully awake

Serious side effects:

• Severe allergic reactions (trouble breathing, hives, swelling of the face, lips, tongue, or throat)

Interactions with high risk of serious adverse effects and should be avoided:

• Sodium Oxybate
• Calcium Oxybate
• Magnesium Oxybate
• Potassium Oxybate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alprazolam
• Hydrocodone
• Ketoconazole
• Zolpidem
• Cimetidine
• Rifampin
• Abametapir
• Alfentanil
• Benzhydrocodone
• Bromazepam
• Bromopride
• Buprenorphine
• Butorphanol
• Cannabidiol
• Carbinoxamine
• Ceritinib
• Cetirizine
• Clarithromycin
• Clobazam
• Codeine
• Conivaptan
• Dihydrocodeine
• Doxylamine
• Esketamine
• Fentanyl
• Flibanserin
• Flumazenil
• Fosnetupitant
• Fospropofol
• Gabapentin
• GabapentinEnacarbil
• Hydromorphone
• Ketamine
• Lemborexant
• Levocetirizine
• Levorphanol
• Lofexidine
• Loxapine
• Meclizine
• Meperidine
• Methadone
• Metoclopramide
• Midazolam
• Morphine
• MorphineSulfate Liposome
• Nalbuphine
• Netupitant
• Oxycodone
• Oxymorphone
• Pentazocine
• Periciazine
• Pregabalin
• Propofol
• Remifentanil
• Remimazolam
• Scopolamine
• Sufentanil
• Tapentadol
• Tramadol
• Trazodone