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Ampicillin-sulbactam

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generic Unasyn

Unasyn, a combination of ampicillin and sulbactam, is a penicillin-type antibiotic used to treat a variety of bacterial infections in both adults and children. This medication is effective against skin infections like cellulitis, stomach infections, and gynecological infections, including pelvic inflammatory disease. It works by halting the growth of bacteria, aided by sulbactam, which inhibits beta-lactamase, an enzyme that some bacteria produce to resist penicillin antibiotics. Administered through injections into a vein or muscle every six hours, Unasyn is available as both a brand-name and a more affordable generic option. While side effects are uncommon, some patients may experience pain at the injection site or diarrhea. Always consult a healthcare professional for personalized medical advice before using this or any medication.
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1.5 (1-0.5)GM, Ampicillin-sulbactam (30 Solution Reconstituteds)

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CVS

$117.07

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Walgreens

$37.31

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Albertsons

$67.51

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Rite Aid

$106.85

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$115.97

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Ampicillin-sulbactam savings card

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CVS

$117.07

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Ampicillin-sulbactam dosage forms

The average cost for 30 Solution Reconstituteds of Ampicillin-sulbactam (generic Unasyn) at 1.5 (1-0.5)GM is $38.25 with a free coupon. This is 13.25% off the average retail price of $288.75
DosageQuantityPrice fromPer unit
1.5 (1-0.5)GM30 Solution Reconstituteds$38.25$1.27
3 (2-1)GM30 Solution Reconstituteds$57.44$1.91

Ampicillin-sulbactam Warnings

This document outlines crucial safety information and warnings for the use of Unasyn (ampicillin/sulbactam). It is essential to carefully consider these details and discuss any concerns with your healthcare provider.

  • Allergic Reactions: There is a possibility of severe allergic reactions to Unasyn, which can be life-threatening, such as facial swelling and anaphylaxis. Patients with known allergies to antibiotics, particularly penicillin or cephalosporins, should exercise caution. Immediate medical attention is necessary if symptoms like hives, skin rash, redness, lip or tongue swelling, or breathing difficulties occur after taking this medication.

  • Severe Skin Reactions: Although uncommon, Unasyn may cause severe skin reactions, including Stevens-Johnson syndrome (SJS) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. Those with a mononucleosis infection are at higher risk for skin rashes and should avoid using this medication if they have the infection. Seek medical help promptly if you experience skin changes such as rash, blisters, redness, or peeling.

  • Liver Issues: Unasyn use is infrequently associated with liver problems, which could potentially become serious and life-threatening. While liver damage is often reversible, individuals with a history of liver issues should be cautious.

  • Clostridioides Difficile Infection: The use of Unasyn may increase the risk of Clostridioides difficile (C. diff) infection, causing severe diarrhea. Antibiotics can alter the balance of normal bacteria in the digestive tract, leading to an overgrowth of C. diff.

Conditions that contraindicate the use of this medication include:

  • A serious allergy to beta-lactam antibiotics such as penicillins and cephalosporins.
  • A history of liver problems related to the use of Unasyn.

Please ensure to discuss any of these conditions with your healthcare provider to avoid adverse effects.

Ampicillin-sulbactam Side Effects

Common side effects:

  • nausea
  • vomiting
  • diarrhea
  • headache
  • pain at the injection site
  • rash

Less common but important to monitor:

  • chest pain
  • itching
  • yeast infections
  • oral thrush
  • new vaginal yeast infection

Serious side effects:

  • severe allergic reactions
  • serious skin reactions
  • severe intestinal condition due to C. difficile bacteria
  • liver problems

Ampicillin-sulbactam Interactions

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Ampicillin-sulbactam FAQs
What is ampicillin-sulbactam used for?

Ampicillin-sulbactam is used to treat a variety of bacterial infections. It is commonly prescribed for infections of the skin, respiratory tract, urinary tract, and abdominal infections, among others. The combination of ampicillin, an antibiotic, and sulbactam, a beta-lactamase inhibitor, helps to overcome bacterial resistance and enhance the effectiveness of the treatment.

Unasyn and Augmentin are not the same. Unasyn is a combination of ampicillin and sulbactam, while Augmentin is a combination of amoxicillin and clavulanate. Both are antibiotics used to treat bacterial infections, but they contain different active ingredients and may be used for different types of infections.

The oral version of ampicillin-sulbactam is amoxicillin-clavulanate, commonly known by the brand name Augmentin.

Yes, ampicillin-sulbactam is the generic name for the brand name drug UNASYN. They contain the same active ingredients and are used for similar purposes.

A substitute for UNASYN, which is a combination of ampicillin and sulbactam, could be another antibiotic that covers similar bacterial infections. Options may include combinations like piperacillin-tazobactam or amoxicillin-clavulanate, depending on the specific infection and patient factors. It is important for a healthcare provider to determine the most appropriate alternative based on the patient's medical history and the sensitivity of the bacteria involved.