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This safety and warning guide provides essential information regarding the use of Unasyn (ampicillin/sulbactam). It is crucial to understand the potential risks and precautions to take when using this medication. Please consult your healthcare provider if you have any questions or concerns.

• Allergic Reactions: Unasyn can cause severe allergic responses, which may include life-threatening symptoms such as facial swelling and anaphylaxis, characterized by the throat closing. If you are allergic to antibiotics, especially penicillin or cephalosporins, inform your healthcare team. Seek immediate medical attention if you experience hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using Unasyn.

• Severe Skin Reactions: Rare but serious skin reactions like Stevens-Johnson syndrome (SJS) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome may occur. Avoid using Unasyn if you have a mononucleosis infection, as it may increase the risk of skin rash. Obtain urgent medical care if you notice skin changes, such as rashes, blisters, skin redness, or skin peeling.

• Liver Problems: Although uncommon, Unasyn may cause liver issues, which can sometimes be severe and life-threatening. This medication should be used cautiously if you have a history of liver problems, and liver damage from Unasyn may be reversible.

• Clostridioides difficile Infection: The use of Unasyn can elevate the risk of infection with Clostridioides difficile (C. diff), leading to severe diarrhea. This occurs because antibiotics can alter the normal bacteria in your stomach and intestines, allowing C. diff to overgrow.

Contraindications: Do not use Unasyn if you have:

• A serious allergy to beta-lactam antibiotics, such as penicillins or cephalosporins.
• A history of liver problems caused by Unasyn use.

In case of overdose or if you experience any severe symptoms, seek emergency medical assistance immediately. Always communicate with your healthcare provider regarding any pre-existing conditions or allergies before starting Unasyn.

When taking this medication, you may experience some common side effects, which are generally mild. These include nausea, vomiting, diarrhea, and pain at the injection site. If this medication is injected into a muscle, pain may occur at the site, while intravenous injections may cause less frequent pain. Some individuals might also develop a mild rash, which is usually not serious, but it's important to consult a healthcare provider if it persists or worsens. Diarrhea and rash are also possible, with diarrhea reported in a small percentage of users.

More serious side effects, though rare, require immediate medical attention. These include severe allergic reactions characterized by hives, rash, blisters, swelling of the lips or tongue, and difficulty breathing. Liver issues can arise, indicated by persistent nausea, stomach pain, yellowing of the skin or eyes, and dark urine. Additionally, there is a risk of a severe intestinal condition due to C. difficile, which can present as persistent diarrhea, abdominal pain, or blood in the stool.

Prolonged use of this medication might lead to oral thrush or a yeast infection, noticeable by white patches in the mouth or changes in vaginal discharge. If these symptoms occur, consult your healthcare provider for advice. Always seek medical help if you notice any unexpected side effects or symptoms not listed.