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This medication comes with important safety warnings that should be carefully considered. Consult your healthcare provider if you have any questions or concerns about these risks:

• Kidney Issues: Some individuals using mesalamine have experienced kidney-related problems, including kidney stones, damage, or even failure. The risk increases for those with a history of kidney issues or those using other kidney-affecting drugs, such as NSAIDs. Inform your healthcare provider about your medical history and all medications you currently use or plan to use.

• Acute Intolerance Syndrome: A rare but possible reaction to mesalamine includes symptoms similar to a UC flare-up, such as stomach pain, bloody diarrhea, fever, headache, and rash. If these occur, you may need to discontinue the medication, so it's important to notify your healthcare provider.

• Liver Problems: Mesalamine may cause liver issues, which can be serious for those with pre-existing liver conditions. Report any signs of liver dysfunction, like jaundice, dark urine, fatigue, or right-sided abdominal pain, to your healthcare provider immediately.

• Allergic Reactions: Although rare, severe allergic reactions to mesalamine can occur, potentially affecting breathing and causing serious rashes or organ issues. Seek immediate medical attention if you experience symptoms like itching, hives, difficulty breathing, or swelling of the face or lips.

• Iron Content in Tablets/Capsules: Certain mesalamine tablets and capsules contain iron oxide. If you are taking iron supplements or have conditions that increase iron levels, discuss potential risks with your healthcare provider.

• Phenylketonuria (PKU) Concerns: The Apriso extended-release capsules contain phenylalanine, which can be harmful to individuals with PKU. If you have this genetic condition, consult your healthcare provider for alternative mesalamine versions.

Contraindications indicate when this medication should not be used due to serious health risks:

• Salicylate Allergy: Do not use mesalamine if you have an allergy to aspirin or other salicylates. Always inform your healthcare provider of any allergies you have.

When taking this medication, you might experience some common side effects like headache, stomach upset, nausea, vomiting, constipation, diarrhea, and indigestion. These effects are generally mild, and in most cases, they diminish as your body adjusts to the medication. However, if they persist or become bothersome, it's advisable to consult your healthcare provider for guidance.

In some instances, additional side effects such as belching, loss of appetite, gas, dizziness, back pain, or symptoms resembling a common cold could occur. Although these are less common, monitoring your symptoms is important, and seeking advice from a healthcare professional is recommended if they intensify.

Serious side effects are rare but require immediate medical attention. These include worsening symptoms of ulcerative colitis, such as increased abdominal pain or bloody diarrhea. Other serious side effects involve potential kidney issues, characterized by changes in urination, blood in the urine, or back pain. Liver problems may also arise, indicated by yellowing of the skin or eyes, dark urine, and severe stomach pain. Allergic reactions, though rare, can be severe and include symptoms like rash, swelling of the face or throat, and difficulty breathing. A severe skin reaction, presenting as blisters or peeling skin, may also occur. If you experience any of these serious symptoms, seek urgent medical care.

While taking Mesalamine, avoid using it in conjunction with Balsalazide, olsalazine, or Sulfasalazine, as these drugs are very similar and may cause unwanted effects. Additionally, Mesalamine can interfere with some laboratory tests, like urine normetanephrine levels, potentially leading to false results. It's important to inform all healthcare providers and lab personnel that you are using Mesalamine.

Mesalamine may also interact with other medications or supplements. Inform your doctor and pharmacist about all medicines and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products. Some medications that are usually not recommended to be used with Mesalamine include a variety of anti-inflammatory drugs and others like Aceclofenac, Ibuprofen, Naproxen, Mercaptopurine, and many more. If such medications are necessary, your doctor may adjust the dosage or frequency.

Additionally, using Mesalamine with Tamarind or Warfarin may increase the risk of side effects, but it could also be necessary for your treatment. In such cases, your doctor might alter the dosage or schedule of either medication. Always follow your doctor's guidance when using these combinations.