Bicillin C-r 900/300 Coupons & Savings Card – Discount Prices from $233.37

Bicillin C-R 900/300 is a combination antibiotic containing penicillin G benzathine and penicillin G procaine, administered via deep intramuscular injection. It's crucial to be aware of specific safety warnings associated with its use to ensure proper administration and minimize risks.

Administration Precautions

This medication is strictly for deep intramuscular injection only. Injecting it into a vein (intravenously) or mixing it with intravenous solutions is dangerous and has been linked to severe complications, including cardiorespiratory arrest and death. Therefore, it should never be administered intravenously. Additionally, care must be taken to avoid injecting into or near arteries or nerves, as such errors can lead to serious neurovascular damage, potentially resulting in permanent paralysis or tissue death. To prevent these risks, healthcare providers should follow proper injection techniques and site selection.

Allergic Reactions

Serious and sometimes fatal allergic reactions, including anaphylaxis, have occurred in patients receiving penicillin therapy. Individuals with a history of penicillin hypersensitivity or sensitivity to multiple allergens are at a higher risk. Before starting treatment with Bicillin C-R 900/300, it's essential to inform your healthcare provider about any previous allergic reactions to penicillins, cephalosporins, or other allergens. If an allergic reaction occurs, the medication should be discontinued immediately, and appropriate emergency treatment should be sought.

Severe Skin Reactions

In rare cases, severe skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and other serious conditions have been reported with penicillin use. If you notice symptoms like a widespread rash, blistering, or peeling skin, seek medical attention promptly.

Methemoglobinemia Risk

The procaine component in Bicillin C-R 900/300 can, in rare instances, lead to methemoglobinemia—a condition where the blood carries less oxygen. Symptoms may include pale or blue-colored skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue. Certain individuals, such as those with specific genetic conditions, infants under six months, or those with heart or lung diseases, may be more susceptible. If you experience any of these symptoms, contact your healthcare provider immediately.

Clostridioides difficile-Associated Diarrhea (CDAD)

Antibiotic use, including Bicillin C-R 900/300, can sometimes lead to an overgrowth of Clostridioides difficile bacteria in the colon, causing severe diarrhea. This condition can range from mild to life-threatening. If you develop watery or bloody stools, with or without stomach cramps and fever, even up to two months after treatment, inform your healthcare provider promptly.

Use in Specific Populations

If you are pregnant, planning to become pregnant, or breastfeeding, discuss with your healthcare provider whether Bicillin C-R 900/300 is appropriate for you. While penicillin G has not shown harmful effects in animal studies, adequate studies in pregnant women are lacking. Penicillin G is excreted in breast milk, so caution is advised when administering this medication to nursing mothers.

By understanding and adhering to these safety warnings, patients and healthcare providers can work together to use Bicillin C-R 900/300 effectively while minimizing potential risks.

Bicillin C-R 900/300 is an antibiotic used to treat various bacterial infections. While effective, it can cause side effects ranging from mild to severe. Common Side Effects:

• Injection Site Reactions: Pain, swelling, or redness at the injection site.
• Gastrointestinal Issues: Nausea, vomiting, or diarrhea. Serious Side Effects:
• Allergic Reactions: Symptoms may include skin rashes, hives, itching, swelling of the face or throat, difficulty breathing, or dizziness.
• Severe Skin Reactions: Conditions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) can occur, characterized by blistering, peeling skin, and flu-like symptoms.
• Methemoglobinemia: A rare blood disorder that reduces oxygen delivery to tissues. Signs include pale or blue-colored skin, lips, or nails; headache; dizziness; rapid heartbeat; or fatigue.
• Clostridioides difficile-associated Diarrhea (CDAD): Severe, persistent diarrhea that may occur during or after treatment.
• Neurological Effects: Symptoms such as confusion, agitation, hallucinations, seizures, or numbness and tingling in the limbs.
• Cardiovascular Issues: Irregular heartbeat, chest pain, or low blood pressure. Injection-Related Complications: Improper administration can lead to serious complications, including nerve damage, tissue death, or severe pain and swelling in the limbs. Important Considerations: Individuals with a history of allergies, asthma, or sensitivity to penicillin or procaine are at higher risk for adverse reactions. Elderly patients and infants under six months may be more susceptible to certain side effects, such as methemoglobinemia. If you experience any severe or concerning symptoms after receiving Bicillin C-R 900/300, seek immediate medical attention.

When taking Bicillin C-R 900/300, it's important to be aware of potential interactions with other medications:

• Tetracycline Antibiotics: These can reduce the effectiveness of penicillin. It's advisable to avoid using them together.

• Probenecid: This medication can increase and prolong penicillin levels in the blood by slowing its excretion.

• Medications That May Cause Methemoglobinemia: Bicillin C-R 900/300 contains procaine, a local anesthetic that can lead to methemoglobinemia—a condition where the blood's ability to carry oxygen is reduced. The risk increases when combined with certain drugs, including:

  • Nitrates/Nitrites: Such as Nitroglycerin and nitroprusside.

  • Other Local Anesthetics: Including Lidocaine and tetracaine.

  • Antineoplastic Agents: Like Cyclophosphamide and ifosfamide.

  • Antibiotics: Such as Dapsone and sulfonamides.

  • Antimalarials: Including chloroquine and Primaquine.

  • Anticonvulsants: Like Phenobarbital and sodium valproate.

  • Other Drugs: Such as Acetaminophen and Metoclopramide.

  Combining these medications with Bicillin C-R 900/300 may increase the risk of developing methemoglobinemia. Symptoms can appear immediately or several hours after exposure and may include skin discoloration (gray or blue), headache, dizziness, fatigue, shortness of breath, rapid heart rate, and confusion. If you experience any of these symptoms, seek medical attention promptly.

Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking to ensure safe and effective use of Bicillin C-R 900/300.