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Oxycodone is a medication that requires careful use due to its potential risks and side effects. Below is a summary of important safety information and warnings associated with its use:

• Risk of Abuse and Addiction: Oxycodone is a controlled substance with a high potential for misuse and addiction. Follow your healthcare provider's prescription precisely and do not alter your dosage without consulting them. Individuals with a personal or family history of substance use disorders or mental health issues may be at increased risk.

• Respiratory Depression: This medication can cause dangerously slow breathing, which can be life-threatening. This risk is heightened at the start of treatment, after a dose increase, or if taken incorrectly. Conditions like COPD, asthma, or a head injury, as well as the use of alcohol or other medications that suppress breathing, can elevate this risk.

• Opioid Overdose Risk: Taking more oxycodone than prescribed can lead to overdose, which is potentially fatal. Keep the medication out of reach of children, pets, and visitors to prevent accidental ingestion.

• Impaired Cognition and Drowsiness: Oxycodone may cause significant drowsiness and impair concentration. Avoid combining it with alcohol or other sedatives, as this can exacerbate these effects, particularly in older adults.

• Drug Interactions: Oxycodone can interact with various medications. Inform your healthcare provider of all the medications you are taking to avoid adverse interactions. Do not adjust your medication dosage without professional guidance.

• Pregnancy and Newborn Risks: Prolonged use during pregnancy can lead to physical dependence in the unborn baby, resulting in withdrawal symptoms after birth. Pregnant individuals should use the smallest effective dose for the shortest duration necessary.

• Physical Dependence and Withdrawal: Long-term use can lead to physical dependence. Withdrawal symptoms may occur if the medication is abruptly stopped or the dose is quickly reduced. Symptoms include anxiety, restlessness, and chills.

• Low Blood Pressure: Oxycodone can cause a drop in blood pressure, potentially leading to dizziness or fainting. Stand up slowly from sitting or lying positions to reduce this risk.

• Adrenal Insufficiency: Long-term use may lead to low adrenal hormone levels, resulting in symptoms such as fatigue, dizziness, and nausea. If suspected, medical intervention may be necessary.

• Seizures: Oxycodone may increase seizure risk in individuals with a history of seizures. Seek immediate medical attention if a seizure occurs.

• Contraindications: Oxycodone should not be used by individuals with severe respiratory depression, severe asthma, gastrointestinal blockages, or those allergic to the medication.

In case of overdose, signs such as slow or shallow breathing, severe drowsiness, or difficulty waking up require immediate medical attention. Having naloxone available and educating family members on its use can be life-saving. Always store oxycodone securely to prevent misuse or theft.

Common side effects:

• nausea
• constipation
• vomiting
• dizziness
• lightheadedness
• drowsiness
• sleepiness
• headache
• weakness
• itching
• trouble sleeping

Less common but important to monitor:

• stomach pain
• chills
• diarrhea
• cough
• shortness of breath

Serious side effects:

• dangerously slow or shallow breathing
• fainting
• seizures
• severe drowsiness
• confusion
• hallucinations
• difficulty waking up
• allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Alcohol
• Marijuana (cannabis)
• Sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem)
• Muscle relaxants (e.g., carisoprodol, cyclobenzaprine)
• Antihistamines (e.g., cetirizine, diphenhydramine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Mixed opioid agonists/antagonists (e.g., butorphanol, nalbuphine, pentazocine)
• Naltrexone
• Samidorphan
• Opioid pain or cough relievers (e.g., codeine, hydrocodone)
• Azole antifungals (e.g., ketoconazole)
• Macrolide antibiotics (e.g., erythromycin)
• Mifepristone
• HIV medications (e.g., tipranavir)
• Rifamycins (e.g., rifabutin, rifampin)
• Ritonavir
• Seizure medications (e.g., carbamazepine, phenytoin)