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This medication carries significant safety concerns that you must be aware of before use. It is critical to understand these risks and consult your healthcare provider with any questions or issues.

• Risk to Unborn Babies: Aliskiren (Tekturna) can severely harm or lead to the death of an unborn baby if taken during pregnancy. It is crucial to avoid pregnancy while on this medication. If you are pregnant, planning to become pregnant, or suspect you might be, contact your healthcare provider immediately and discontinue use.

• Allergic Reactions: Be vigilant for serious allergic reactions, which may include swelling of the face, throat, or extremities, and difficulty breathing. Anaphylaxis and angioedema are possible. Seek emergency medical assistance if you experience any of these symptoms.

• Low Blood Pressure: This drug may cause a drop in blood pressure, resulting in dizziness or lightheadedness, particularly at the onset of treatment. Symptoms are exacerbated by dehydration, low salt levels, or concurrent use of other blood pressure medications. These effects typically subside with continued use.

• High Potassium Levels (Hyperkalemia): Aliskiren (Tekturna) may elevate potassium levels, potentially disrupting heart rhythm. Those with kidney issues or on potassium-raising medications are at increased risk. Regular blood tests will be necessary to monitor potassium levels. Report symptoms such as muscle weakness, chest pain, tingling, or irregular heartbeat to your provider promptly.

• Kidney Concerns: This medication can impair kidney function, occasionally leading to kidney failure. Individuals with pre-existing kidney conditions or those on other kidney-affecting drugs are at higher risk. Periodic blood tests are required to monitor kidney health. Notify your provider if you experience reduced urination or dark urine despite adequate hydration.

• Interactions with ACE Inhibitors or ARBs: Aliskiren (Tekturna) should not be used by individuals with diabetes who are also taking ACE inhibitors or ARBs, as this combination increases the risk of severe kidney damage, elevated blood potassium, and dangerously low blood pressure. Avoid using Aliskiren (Tekturna) with these medications if you have kidney issues.

• Dangerous Drug Interactions: Avoid taking Aliskiren (Tekturna) with cyclosporine (Neoral or Sandimmune) or itraconazole (Sporanox), as these combinations can significantly increase Aliskiren levels in the body, leading to serious side effects. Inform your healthcare provider about all medications you are currently using.

Ensure you discuss any of these concerns with your healthcare provider to ensure safe and effective use of this medication.

Common side effects:

• Dizziness
• Lightheadedness
• Cough
• Diarrhea
• Tiredness
• Stomach pain
• Indigestion
• Acid reflux

Serious side effects:

• Serious allergic reaction (rash, itching, swelling of the face, tongue, or throat, severe dizziness, trouble breathing)
• High potassium levels (muscle weakness, nausea, chest pain, tingling or numbness, irregular heartbeat)
• Kidney-related issues (changes in urination, fatigue, confusion, swelling in the feet or ankles)
• Seizures

Interactions with high risk of serious adverse effects and should be avoided:

• Azilsartan
• Azilsartan Medoxomil
• Benazepril
• Candesartan
• Captopril
• Enalapril
• Enalaprilat
• Eprosartan
• Fosinopril
• Irbesartan
• Lisinopril
• Losartan
• Moexipril
• Olmesartan Medoxomil
• Perindopril
• Quinapril
• Ramipril
• Telmisartan
• Trandolapril
• Valsartan

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Capmatinib
• Cyclosporine
• Itraconazole
• Lasmiditan
• Simeprevir
• Venetoclax

Interactions with low risk that usually do not require a change in therapy:

• Furosemide
• Rifampin