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The following safety and warning information provides crucial guidance on the use of Diovan HCT (valsartan/hydrochlorothiazide). It is essential to be aware of these potential risks and precautions to ensure safe use. Please consult your healthcare provider if you have any questions or concerns.

• Pregnancy Warning: Diovan HCT should not be used during pregnancy as it can cause severe harm to an unborn baby, potentially leading to life-threatening conditions such as low blood pressure, kidney issues, low platelets, jaundice, or even death. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, discuss alternative blood pressure treatments with your healthcare provider. If pregnancy occurs while on this medication, discontinue use immediately and contact your provider.

• Low Blood Pressure: This medication can lead to decreased blood pressure, causing dizziness or lightheadedness, especially when standing up quickly. The risk increases if you are on other blood pressure-lowering drugs or if you are dehydrated. If dizziness occurs, consult your provider to assess the need for dosage adjustment or an alternative medication.

• Kidney Function: Diovan HCT may impair kidney function, especially in patients with severe heart failure, existing kidney problems, or those on medications affecting the kidneys. Regular lab tests may be required to monitor kidney health. Report any reduction in urination or swelling to your provider immediately.

• Severe Allergic Reactions: Rarely, this medication can cause life-threatening allergic reactions. Seek emergency medical attention if you experience swelling of the lips, tongue, face, or throat, or if you have difficulty breathing.

• Electrolyte Imbalance: This medication can alter electrolyte levels, such as sodium, potassium, and magnesium. Your provider may perform blood tests to monitor these levels. Symptoms like nausea, irregular heartbeats, muscle cramps, or excessive thirst should be reported, as they may indicate imbalances.

• Vision Changes: Any changes in vision or eye pain occurring within hours to weeks of starting this medication should prompt immediate discontinuation and consultation with your provider, as they could lead to permanent vision loss if untreated.

• Lupus Flare-Up: Hydrochlorothiazide, a component of Diovan HCT, may exacerbate lupus symptoms. Discuss the risks and benefits with your provider if you have a lupus history.

• Drug Interactions: Diovan HCT can interact with various medications, affecting their efficacy or safety. Inform your healthcare provider of all medications you are taking, including prescriptions, over-the-counter drugs, and supplements, particularly lithium, NSAIDs, or carbamazepine.

Contraindications: Avoid using Diovan HCT if you have the following conditions:

• An inability to produce urine.
• Allergy to sulfa drugs.
• Concurrent use of aliskiren (Tekturna) if you have diabetes.

For any concerns or in the event of an overdose, contact your healthcare provider or seek emergency medical assistance immediately.

When taking this medication, some individuals may experience common side effects such as dizziness or lightheadedness, particularly when standing up quickly from a sitting or lying position. These effects are usually mild and often subside as your body adjusts to the medication. If they persist or worsen, consider consulting your healthcare provider.

Other reported side effects include symptoms like muscle cramps, stomach upset, dry mouth, nausea, headaches, and rashes. While these are generally not severe, it’s important to monitor them and seek advice if they become troublesome.

In rare cases, more serious side effects may occur, requiring immediate medical attention. These include severe allergic reactions characterized by rash, swelling of the face or throat, and difficulty breathing. Additionally, severe low blood pressure may present as fainting or significant dizziness. Kidney issues might manifest as reduced urination, swelling, or unexplained weight gain. Changes in electrolyte levels could result in nausea, chest pain, irregular heartbeat, intense thirst, or muscle cramps. These symptoms should not be ignored and warrant prompt medical consultation.

Overall, while many people using this medication do not experience serious side effects, staying vigilant and informed is crucial for your health and safety.

When taking Diovan HCT (Valsartan/Hydrochlorothiazide), it's essential to be aware of potential interactions with other medications. Some drugs should not be combined with Diovan HCT, such as Aliskiren and Dofetilide, as they may lead to adverse effects. Additionally, certain medications, including Benazepril, Lisinopril, Lithium, and those that can raise potassium levels in the blood, like sparsentan and birth control pills containing drospirenone, may require caution or dosage adjustments if used together.

Moreover, this medication may interfere with specific lab tests, such as those assessing parathyroid function, potentially causing inaccurate results. Therefore, it is crucial to inform your healthcare providers and lab personnel about your use of Diovan HCT.

Furthermore, some over-the-counter products, like NSAIDs (e.g., Ibuprofen, Naproxen), cough-and-cold remedies, and diet aids, might increase blood pressure or exacerbate heart failure. Always consult your doctor or pharmacist about all the medications and supplements you are taking to ensure safe usage and avoid potential interactions.