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This safety information highlights crucial warnings and precautions for the use of this medication. Please read the following points carefully and consult your healthcare provider if you have any questions or concerns.

• Liver Damage: Erythromycin can lead to severe or potentially fatal liver damage, especially in individuals with a history of liver issues. If you notice symptoms such as unexplained abdominal pain, nausea, vomiting, dark urine, pale stools, or yellowing of the skin or eyes, seek medical attention immediately. Regular blood tests may be required to monitor liver health.

• Heart Rhythm Changes (QT Prolongation): Erythromycin may rarely cause a serious heart condition known as QT prolongation, which can be life-threatening. Individuals with specific heart conditions, those over 65, or those taking other medications affecting heart rhythm are at higher risk. Inform your healthcare provider of any heart conditions and all medications, including over-the-counter products and supplements, before starting erythromycin.

• Syphilis in Infants: Treating syphilis during pregnancy with erythromycin may not fully prevent the infection in newborns, as the drug might not effectively reach the baby. Inform your healthcare provider and your child’s doctor if you used erythromycin for syphilis during pregnancy, as your baby may require antibiotics after birth.

• Severe Diarrhea: Erythromycin, like other antibiotics, can increase the risk of Clostridioides difficile-associated diarrhea (CDAD), a potentially fatal condition. If you experience bloody or watery stools, discontinue use and contact your healthcare provider immediately. Risks increase with the use of multiple or long-term antibiotics, age over 65, recent hospitalization, or weakened immune systems.

• Drug Interactions: Erythromycin can interact with numerous medications, some interactions may be life-threatening. Avoid taking erythromycin with drugs that impact heart rhythm.

• Myasthenia Gravis Worsening: Erythromycin may exacerbate symptoms of myasthenia gravis, such as muscle weakness and breathing difficulties. If you have a history of this condition, discuss the potential risks with your healthcare provider.

• Intestinal Blockage in Infants: Prolonged use of erythromycin in infants can lead to a blockage between the stomach and small intestine. This medication is typically prescribed to infants only for severe illnesses. Monitor infants for signs of vomiting or fussiness during feeding and contact their healthcare provider if these occur.

Contraindications: This medication should not be used if you are taking any of the following substances, as they can pose severe health risks:

• Terfenadine, astemizole, pimozide, cisapride, ergotamine, or dihydroergotamine.
• Lovastatin or simvastatin (Zocor).

If any of these apply to you, consult your healthcare provider before starting erythromycin.

When taking this medication, you may experience common side effects such as nausea, vomiting, diarrhea, stomach pain or cramping, and loss of appetite. These are generally mild and may improve if you take the medication with food. If these symptoms persist or worsen, it's important to consult your healthcare provider for advice.

Some users have reported other side effects, including rash, hives, and hearing loss. While these are less common, you should contact your healthcare provider if you experience them, especially if they are severe.

There are rare but serious side effects that require urgent medical attention. These include signs of liver damage such as persistent nausea or vomiting, yellowing of the skin or eyes, dark urine, and severe stomach pain. Abnormal heart rhythms, characterized by dizziness, fainting, or a fast or irregular heartbeat, also necessitate immediate care.

This medication can sometimes lead to a severe intestinal condition known as Clostridioides difficile-associated diarrhea (CDAD), which presents as persistent diarrhea, abdominal pain, and bloody or mucus-filled stool. If you experience these symptoms, avoid using anti-diarrhea or opioid products as they may worsen the condition.

In rare cases, a serious allergic reaction may occur, indicated by symptoms such as rash, swelling of the face or throat, severe dizziness, or difficulty breathing. Immediate medical help is crucial if these symptoms arise. Additionally, prolonged use may result in oral thrush or a yeast infection, so contact your healthcare provider if you notice white patches in your mouth or changes in vaginal discharge. Always stay alert to any new symptoms and reach out to your healthcare provider if you have concerns.

Erythromycin can interact with several medications, influencing how it or the other drugs work in your body. It's essential to inform your doctor and pharmacist about all the medications and supplements you take, including those prescribed or over-the-counter, as well as vitamins and herbal supplements. Here are some key interactions:

1. Drugs Not Recommended with Erythromycin: Some medications should not be used with erythromycin, as these combinations can lead to serious health risks. These include drugs like astemizole, cisapride, pimozide, and certain statins like lovastatin and simvastatin. If these medications are necessary, your doctor may need to adjust your treatment plan.

2. Drugs Usually Not Recommended: In certain cases, erythromycin may be prescribed alongside other medications, despite potential interactions. These include drugs that affect heart rhythm, such as amiodarone and procainamide, and medications like alprazolam and diltiazem. If used together, your healthcare provider may adjust the dosages.

3. Increased Risk of Side Effects: Some medications, when used with erythromycin, may increase the likelihood of side effects. These include anticoagulants like warfarin, and medications such as sildenafil or certain corticosteroids. Your doctor may monitor you more closely if both medications are necessary.

4. Erythromycin's Effect on Other Drugs: Erythromycin can slow down how your body processes other drugs, potentially increasing their effects. This includes drugs like colchicine, benzodiazepines such as midazolam, and certain erectile dysfunction treatments like tadalafil.

5. Impact on Lab Tests: Erythromycin may affect certain laboratory tests, possibly leading to incorrect results. It is important to inform lab personnel and all healthcare providers that you are taking this medication.

Always consult with your healthcare provider before starting or stopping any medication to ensure safe and effective use.