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Estrogen therapy, whether used alone or in combination with another hormone like progestin for postmenopausal replacement therapy, can lead to rare but severe side effects. It is crucial to weigh the benefits and risks of hormone treatment in consultation with your doctor, considering your personal health history.

Key Safety Information:

• Estrogens have been linked to an increased risk of uterine cancer (endometrial cancer). The risk is reduced when estrogen is taken with progestin. Report any unusual vaginal bleeding to your doctor immediately.
• In postmenopausal individuals, estrogens, with or without progestin, may heighten the risk of breast and ovarian cancers, stroke, dementia, and serious blood clots. When combined with progestin, the risk of heart disease, including heart attacks, also increases. The duration of use and the estrogen dosage can influence these risks.
• To minimize the risk of severe side effects from prolonged use, this medication should be administered for the shortest duration and at the lowest effective dose. Regular consultations with your doctor, ideally every 3 to 6 months, are advised to reassess the necessity of continued treatment.
• Estrogen-containing products are not recommended for the prevention of heart disease or dementia.
• If you are on long-term estrogen therapy, it is important to undergo a comprehensive physical examination at least annually or as recommended by your healthcare provider.

This information aims to ensure that you use this medication safely and effectively. Always follow your healthcare provider's guidance and report any concerns promptly.

You may experience some common side effects such as dizziness, lightheadedness, headache, upset stomach, bloating, nausea, weight fluctuations, changes in sexual interest, or breast tenderness. These are generally mild and should ease over time. If they persist or worsen, consider discussing them with your healthcare provider.

It is important to monitor your blood pressure since this medication can cause an increase. Inform your healthcare provider if you notice elevated readings, as adjustments might be necessary.

More serious side effects, although uncommon, require immediate attention. These include signs of liver issues like persistent nausea, yellowing of the skin or eyes, dark urine, and severe abdominal pain. Additionally, be alert to mood changes, unexpected breast lumps, swelling in the extremities, unusual vaginal symptoms, skin color changes, fatigue, or worsening seizures.

Women using this medication should be cautious of signs of masculinization, such as voice changes, facial hair growth, and changes in menstrual cycles. If these occur, stop the medication and consult your healthcare provider promptly to prevent permanent changes.

Rarely, this medication may lead to severe blood clot issues, such as heart attacks or strokes. Urgent medical help is needed for symptoms like chest pain, shortness of breath, sudden dizziness, or severe headaches.

Though uncommon, severe allergic reactions can occur. Seek immediate medical attention if you experience symptoms like rash, severe dizziness, or difficulty breathing. Always communicate any unlisted side effects to your healthcare provider for further guidance.