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This medication contains estrogen, and in some cases, another hormone called progestin, which are used for hormone replacement therapy after menopause. However, there are important safety considerations and potential risks that you need to be aware of when using this therapy. It is crucial to discuss these risks, the benefits of treatment, and your personal health history with your doctor.

• Cancer Risks: Estrogen therapy has been linked to an increased risk of uterine (endometrial) cancer, especially when used without progestin. Using progestin alongside estrogen can reduce this risk. In postmenopausal women, estrogen, whether used alone or with progestin, can elevate the risk of breast and ovarian cancer, stroke, dementia, and serious blood clots. When combined with progestin, there is also an increased risk of heart disease, including heart attacks. To minimize these risks, it is recommended to use the lowest effective dose for the shortest duration possible. Regular consultations with your doctor (every 3 to 6 months) are advised to review the necessity of continued treatment.

• Heart and Blood Clot Risks: Estrogen-containing medications, such as Covaryx, can heighten your risk of developing blood clots, which may lead to conditions like deep vein thrombosis or pulmonary embolism. These clots have the potential to cause heart attacks or strokes if they travel to the heart or brain. Individuals with a personal or family history of blood clots, heart disease, high blood pressure, diabetes, high cholesterol, or those who smoke are at an increased risk. Therefore, this medication should not be used as a preventive measure for heart disease.

• Pregnancy and Fetal Harm: Covaryx should not be used by individuals who are pregnant or may become pregnant due to potential harm to the unborn baby.

• Liver and Gallbladder Concerns: Estrogens and methyltestosterone might increase your risk of liver damage and gallbladder disease. If you have a history of liver disease, jaundice, or experience symptoms like yellowing of the skin or eyes, severe stomach pain, or dark urine, contact your healthcare provider immediately.

• Calcium Levels: This medication can cause elevated calcium levels in the blood, particularly in those with breast cancer or bone-metastatic cancer. Symptoms such as fatigue, muscle weakness, and kidney problems should be reported to your provider.

• Fluid Retention: Covaryx may cause fluid retention, leading to weight gain and swelling. Those with heart, kidney, or liver conditions should be vigilant for these symptoms.

• Regular Monitoring: If you are on extended hormone therapy, regular physical exams and breast examinations (such as mammograms) are essential. Notify your healthcare provider of any unusual changes in your breasts or any abnormal vaginal bleeding immediately.

• Contraindications: Avoid using this medication if you have a history of breast cancer (except in specific cases), estrogen-sensitive tumors, abnormal vaginal bleeding, blood clotting disorders, severe liver damage, or if you are breastfeeding.

Ensure to communicate openly with your healthcare provider about any concerns or symptoms you may experience while using this medication.

Covaryx, which contains esterified estrogens and Methyltestosterone, can interact with various medications, potentially altering their effectiveness or increasing side effects. It’s important to inform your healthcare provider about all medications, supplements, and herbal products you are currently taking.

Some drugs that may interact with Covaryx include Anastrozole, corticosteroids like Prednisone, Exemestane, fezolinetant, ospemifene, Raloxifene, Tamoxifen, and Tranexamic Acid. These interactions can affect how Covaryx works in your body. Additionally, medications such as azole antifungals (e.g., Itraconazole), macrolide antibiotics (e.g., Erythromycin), rifamycins (e.g., Rifabutin), and seizure medications (e.g., Carbamazepine, Phenytoin), as well as St. John's wort, can influence the removal of estrogens from your system, potentially impacting the efficacy of Covaryx.

Covaryx may also interact with blood thinners like Warfarin, increasing the risk of bleeding. Other medications, such as amifampridine, anisindione, bupropion, dicumarol, Donepezil, and phenprocoumon, may require careful monitoring and possible dosage adjustments if used together with Covaryx. Furthermore, combining Covaryx with Ginseng, Levothyroxine, licorice, or tipranavir may lead to heightened side effects.

Lastly, Covaryx might interfere with certain lab tests, leading to inaccurate results. Ensure all healthcare personnel involved in your care are aware you are taking this medication.