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When considering hormone replacement therapy after menopause, it is important to be aware of the potential serious side effects associated with the use of estrogens, either alone or combined with another hormone called progestin. Here are key points to discuss and consider:

• Cancer Risk: Estrogens may increase the risk of uterine (endometrial) cancer. However, the addition of progestin can reduce this risk. Report any unusual vaginal bleeding to your doctor immediately.

• Other Health Risks: In postmenopausal women, the use of estrogens, with or without progestin, can elevate the risk of breast and ovarian cancer, stroke, dementia, and serious blood clots. When combined with progestin, the risk of heart disease, including heart attacks, may also rise. These risks can be influenced by the duration of therapy and the dosage of estrogen. It is recommended to use the lowest effective dose for the shortest duration needed. Regular consultations with your doctor (every 3 to 6 months) are advised to reassess the necessity of continuing this medication.

• Use Limitations: Estrogen-containing products should not be used for the prevention of heart disease or dementia.

• Monitoring: If long-term use of this medication is necessary, annual or doctor-advised physical examinations are essential to monitor your health status.

Discuss these risks and benefits thoroughly with your healthcare provider, considering your personal health history, to make an informed decision regarding hormone therapy.

While taking this medication, you may experience mild side effects such as dizziness, lightheadedness, headaches, upset stomach, bloating, nausea, changes in weight, variations in sexual interest, or breast tenderness. These are generally not serious but if they persist or worsen, consult your healthcare provider. It is important to monitor your blood pressure, as this medication can cause it to rise. If you notice high readings, inform your healthcare provider.

Be vigilant for more serious side effects and seek immediate medical attention if you encounter signs of liver problems like persistent nausea, yellowing skin or eyes, abdominal pain, or dark urine, as well as mental changes like severe depression or memory loss. Additionally, report any breast lumps, swelling in the hands or feet, unusual vaginal bleeding or discharge, changes in skin color, unusual fatigue, or worsening seizures.

Women should be aware of signs of masculinization such as hoarseness, voice deepening, facial hair growth, new or worsening acne, enlarged clitoris, or changes in menstrual periods. If these occur, discontinue the medication and contact your healthcare provider immediately. Rare but serious risks include blood clots, heart attacks, or strokes. Symptoms like shortness of breath, chest pain, sudden severe headaches, or weakness on one side of the body require urgent medical attention.

Though rare, severe allergic reactions can occur. Seek immediate help if you experience a rash, itching, swelling of the face or throat, severe dizziness, or difficulty breathing. Always report any unlisted side effects to your healthcare provider.