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Estrogen therapy, whether used alone or combined with progestin after menopause, can potentially lead to rare but severe side effects. It is crucial to thoroughly discuss the advantages and risks of hormone therapy with your healthcare provider, taking into account your personal medical history.

• Increased Cancer Risk: Estrogens may elevate the risk of uterine (endometrial) cancer. However, using progestin alongside estrogen can reduce this risk. Report any unusual vaginal bleeding to your doctor immediately.
• Other Health Risks: In postmenopausal women, estrogen—alone or with progestin—can heighten the risk of breast and ovarian cancer, stroke, dementia, and severe blood clots. When combined with progestin, the risk of heart disease, including heart attacks, also increases. These risks are influenced by the duration of treatment and the estrogen dosage. To minimize these risks, use the lowest effective dose for the shortest time necessary. Regularly consult your doctor, ideally every 3 to 6 months, to reassess the need for continued use.
• Non-preventive Use: Estrogen products should not be utilized to prevent heart disease or dementia.
• Regular Health Monitoring: If you are on long-term estrogen therapy, it is recommended to undergo a comprehensive physical examination annually or as directed by your healthcare provider.

It is essential to stay informed about the potential side effects and maintain ongoing communication with your healthcare professional to ensure safe and effective use of this medication.

When taking methyltestosterone, you may experience some mild side effects such as dizziness, lightheadedness, headaches, stomach upset, bloating, nausea, changes in weight, altered interest in sex, or breast tenderness. These are usually manageable, but if they persist or worsen, it's important to inform your healthcare provider. Additionally, this medication may increase your blood pressure, so regular monitoring is advised, and any significant changes should be promptly reported.

Serious side effects require immediate attention. Contact your healthcare provider if you experience symptoms of liver disease like persistent nausea, vomiting, yellowing of the skin or eyes, abdominal pain, or dark urine. Mental or mood changes, including severe depression or memory loss, should also be addressed urgently. Other serious symptoms include breast lumps, unusual vaginal bleeding or discharge, and changes in skin color.

Women may notice signs of masculinization, such as a deepened voice, facial hair growth, or menstrual changes. If these occur, discontinuing the medication and consulting your healthcare provider is advised to prevent permanent changes. Rare but severe side effects include blood clot-related events like heart attacks or strokes. Symptoms to watch for include chest pain, shortness of breath, sudden dizziness, severe headaches, and swelling or warmth in the legs.

Allergic reactions are rare but serious. Seek immediate medical help if you experience a rash, itching, swelling, severe dizziness, or trouble breathing. Always consult your healthcare provider for any unlisted effects or concerns.