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When considering the use of this medication, especially in older adults with dementia, it is vital to be aware of potential risks, including serious and possibly fatal side effects. These risks may encompass conditions such as stroke, heart failure, irregular or rapid heartbeat, and pneumonia. It is important to note that this medication is not approved for addressing behavioral issues related to dementia.

• Always discuss with your healthcare provider the potential risks and benefits of this medication, and explore other possibly safer and effective treatment options for dementia-related behavioral problems.
• If this medication is being used alongside other treatments for depression, ensure you thoroughly review the drug information for all medications involved.
• Remain vigilant about any signs of adverse effects and maintain open communication with your healthcare professional to ensure safe and effective treatment.

While taking this medication, you might experience some common side effects such as drowsiness, dizziness, lightheadedness, dry mouth, tiredness, stuffy nose, and weight gain. These effects are usually mild, but if they persist or worsen, it's important to inform your healthcare provider. Be cautious when sitting or lying down as this drug can cause a significant drop in blood pressure, increasing your risk of falls.

More serious side effects that require immediate attention include drooling, difficulty swallowing, persistent cough, fever, tremors, muscle spasms, or interruptions in breathing during sleep. In rare cases, you might experience involuntary movements such as lip smacking or tongue thrusting, which could indicate a condition called tardive dyskinesia. Additionally, this medication could lead to an increase in blood sugar levels, potentially exacerbating diabetes. Monitor for symptoms like increased thirst or urination.

On rare occasions, this drug may elevate prolactin levels, causing unwanted breast milk production, menstrual changes, or fertility issues in females, and sexual dysfunction or breast enlargement in males. A prolonged or painful erection in males requires urgent medical help to prevent long-term problems.

Severe side effects like fainting, a fast or irregular heartbeat, seizures, severe dizziness, or chest pain also demand immediate medical attention. A rare but serious condition called neuroleptic malignant syndrome (NMS) may occur, characterized by symptoms such as fever, muscle stiffness, severe confusion, sweating, and dark urine. An allergic reaction is uncommon but serious, and signs include rash, swelling, severe dizziness, and breathing difficulties. Always seek prompt medical assistance for any severe reactions. Keep in mind this is not an exhaustive list of side effects; if you notice other symptoms, reach out to your healthcare provider.

Keep a detailed list of all the medications and supplements you take, including prescription, non-prescription, and herbal products, and discuss it with your healthcare provider. This is important because some medications can interact with your current treatment. For instance, alpha blockers like prazosin may interact with this drug. Additionally, certain drugs, such as some antidepressants like nefazodone, can influence how iloperidone is processed in your body, potentially altering its effectiveness.

Be aware that many medications, not just iloperidone, can affect heart rhythm, leading to a condition known as QT prolongation. Medicines such as amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and certain antibiotics like erythromycin fall into this category.

Furthermore, inform your doctor or pharmacist if you are using other substances that cause drowsiness. These include opioid pain medications or cough suppressants like codeine and hydrocodone, alcohol, marijuana, sleep aids or anxiety treatments like alprazolam, lorazepam, and zolpidem, muscle relaxants such as carisoprodol and cyclobenzaprine, and antihistamines like cetirizine and diphenhydramine.

Always read the labels on over-the-counter medicines, especially those for allergies or colds, as they might contain ingredients that induce drowsiness. Consult your pharmacist to ensure you are using these products safely.